Imaginal Discs

The Genetic and Cellular Logic of Pattern Formation

Imaginal Discs

Many of the 14,000 genes of Drosophila are involved in the development of imaginal discs. These hollow sacs of cells make adult structures during metamorphosis, and their study is crucial to comprehending how a larva becomes a fully-functioning fly. This book examines the genetic circuitry of the well-known 'fruit fly', tackling questions of cell assemblage and pattern formation, of the hows and the whys behind the development of the fly. After an initial examination of the proximity versus pedigree imperatives, the book delves into bristle pattern formation and disc development, with entire chapters devoted to the leg, wing, and eye. Extensive appendices include a glossary of protein domains, catalogues of well-studied genes, and an outline of signaling pathways. More than 30 wiring diagrams among over 60 detailed schematics clarify the text. No student or practising scientist engaged in the study of Drosophila genetics should be without this comprehensive reference.


 Reviews:

"For the thousands of researchers working with Drosophila melanogaster, this seems like a book that should be on the shelf, ready to hand. Considering it is a hardcover and given the wealth of information that it contains, at just under $120, it seems like good value for the money."
Stephen Higgs, Entomological Society of America

'How wonderful to have such a complete guide and extensive review of imaginal disc development. The comprehensive nature of this book makes it an essential reference. … a wonderful teaching resource. … read and enjoy the history behind the models!' Genetical Research

'This book most certainly fulfils its promise as a comprehensive reference guide and is an exceptional accomplishment for one author … It is well written and has excellent black-and-white figures.' American Entomology

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