Case 35 - Man who stopped drinking  pp. 259-264

Man who stopped drinking

By Mary M. Kenan and Rachel S. Doody

Chapter Abstract

This chapter talks about an 81-year-old, left-handed, Caucasian man who was referred by his internist for evaluation of cognitive change. Initial impression was that of an acute-on-chronic change of cognition and gait, which occurred about a month before the first visit, most likely due to Wernicke's encephalopathy, plus underlying dementia. Potentially contributing factors in the differential diagnosis of the dementia were alcoholism in the past, suspected nutritional insufficiency, possible multi-infarct dementia, and possible Alzheimer's disease. The patient was treated emergently for Wernicke's encephalopathy with intravenous thiamine hydrochloride immediately following the new patient visit. The patient's history suggested both an insidious dementia and an acute change due to some other factor. This case illustrates the importance of obtaining a careful chronology of symptoms in the history, and of entertaining the possibility of both acute and chronic processes.


Keywords:

Wernicke's encephalopathy; gait; alcoholism; dementia; cognition; Alzheimer's disease;

Case 35

Reference Title: References and Further Reading

Reference Type: reference-list

American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders (DSM IV), 4th edn. Washington, DC: American Psychiatric Association.
Cummings JL (1997). The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology, 48(5 Suppl 6), S10–16. Review.
Folstein M , Folstein S , McHugh P (1975). Mini-mental state – practical method for grading cognitive state of patients for clinician. J Psychiat Res, 12, 189–98.
Geschwind MD , Shu H , Haman A , Sejvar JJ , Miller BL (2008). Rapidly progressive dementia. Ann Neurol, 64, 97–108.
Nasreddine ZS , Phillips NA , Bedirian V , et al. (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc, 53, 695–9.
Panisset M , Roudier M , Saxton J , Boller F (1994). Severe impairment battery. A neuropsychological test for severely demented patients. Arch Neurol, 51(1), 41–5.
Pérès K , Helmer C , Amieva H , et al. (2008). Natural history of decline in instrumental activities of daily living performance over the 10 years preceding the clinical diagnosis of dementia: a prospective population-based study. J Am Geriatr Soc, 56(1), 37–44. Epub 2007 Nov 20.
Rossor MN , Fox NC , Mummery CJ , Schott JM , Warren JD (2010). The diagnosis of youngonset dementia. Lancet Neurol, 9(8), 793–806.

Reference Title: References and further reading

Reference Type: reference-list

Craik FIM , Anderson ND , et al. (1995). Memory changes in normal ageing. In Baddeley AD , Wilson BA , Watts FN . Memory Disorders Chichester: Wiley, 211–42.
Dubois B , Albert ML (2004). Amnestic MCI or prodromal Alzheimer's disease? Lancet Neurol, 3(4), 246–8.
Dubois B , Feldman HH , et al. (2007). Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol, 6(8), 734–46.
Ganguli M , Rodriguez E , et al. (2004). Detection and management of cognitive impairment in primary care: The Steel Valley Seniors Survey. J Am Geriatr Soc, 52(10), 1668–75.
Grober E , Buschke H , et al. (1988). Screening for dementia by memory testing. Neurology, 38(6), 900–3.
Hodges J (1998). The amnestic prodrome of Alzheimer's disease. Brain, 121(9), 1601–2.
Lowenthal PM , Berrman PL , et al. (1967). Aging and Mental Disorders: A Social Psychiatric Study. San Francisco (CA): Jossey-Bass.
McGlone J , Gupta S , et al. (1990). Screening for early dementia using memory complaints from patients and relatives. Arch Neurol, 47(11), 1189–93.
Schmand B , Jonker C , et al. (1997). Subjective memory complaints in the elderly: depressive symptoms and future dementia. Br J Psychiatry, 171, 373–6.
Storandt M , Grant EA , et al. (2006). Longitudinal course and neuropathologic outcomes in original vs. revised MCI and in pre-MCI. Neurology, 67(3), 467–73.
Tierney MC , Szalai JP , et al. (1996). The prediction of Alzheimer disease. The role of patient and informant perceptions of cognitive deficits. Arch Neurol, 53(5), 423–7.

Reference Title: References and further reading

Reference Type: reference-list

Flier WM van der , Buchem MA van , Weverling-Rijnsburger AWE , et al. (2004). Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes. J Neurol 251, 671–5.
Glodzik-Sobanska L , Reisberg B , De Santi S , et al. (2007). Subjective memory complaints: presence, severity and future outcome in normal older subjects. Dement Geriatr Cogn Disord 24, 177–84.
Johnson JK , Head E , Kim R , et al. (1999). Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol 56, 1233–9.
Jonker C , Geerlings MI , Schmand B (2000). Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int J Geriatr Psychiatry 15, 983–91.
Norden AG van , Fick WF , Laat KF de , et al. (2008). Subjective cognitive failures and hippocampal volume in elderly with white matter lesions. Neurology, 71, 1152–9.
Reisberg B , Gauthier S (2008). Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease. Int Psychogeriatr 20, 1–16.
Reisberg B , Shulman M , Monteiro I , et al. (2008). A seven-year prospective study of outcome in older persons with and without subjective cognitive impairment. Alzheimers Dement 4, T529.
Stomrud E , Hansson O , Minthon L , et al. (2010). Slowing of EEG correlates with CSF biomarkers and reduced cognitive speed in elderly with normal cognition over 4 years. Neurobiol Aging, 31(2), 215–23.
Visser PJ , Verhey F , Knol DL , et al. (2009). Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. Lancet Neurol 8, 619–27.
Vlies AE van der , Koedam ELGE , Pijnenburg YAL , et al. (2009). Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset. Psychol Med 39, 1907–11.

Reference Title: References and Further Reading

Reference Type: reference-list

Armitage SG (1946). An analysis of certain psychological tests used in the evaluation of brain injury. Psych Mono, 1–48.
Braak H , Braak E (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol, 82, 239–59.
Cairns NJ , Ikonomovic MD , Benzinger T , et al. (2009). Absence of Pittsburgh Compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease. Arch Neurol, 66, 1557–62.
Fagan AM , Mintun MA , Shah AR , et al. (2009). Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease. EMBO Mol Med 1, 371–80.
Folstein MF , Folstein SE , McHugh PR (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189–98.
Goodglass H , Kaplan E (1983). Boston Naming Test Scoring Booklet, Philadelphia, PA: Lea & Febiger.
Grober E , Buschke H , Crystal H , Bang S , Dresner R (1988). Screening for dementia by memory testing. Neurology, 38, 900–3.
Hyman BT , Trojanowski JQ (1997). Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J Neuropathol Exp Neurol 56, 1095–7.
Johnson DK , Storandt M , Morris JC , Galvin JE (2009). Longitudinal study of the transition from healthy aging to Alzheimer disease. Arch Neurol 66, 1254–9.
Khachaturian ZS (1985). Diagnosis of Alzheimer's disease. Arch Neurol 42, 1097–105.
Lawrence J , Davidoff D , Katt-Lloyd D , Auerbach M , Hennen J (2001). A pilot program of improved methods for community-based screening for dementia. Am J Geriatr Psychiatry, 9, 205–11.
Mirra SS , Heyman A , Mckeel D , et al. (1991). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479–86.
Morris JC (1993). The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43, 2412–14.
Petersen RC , Doody R , Kurz A , et al. (2001). Current concepts in mild cognitive impairment. Arch Neurol, 58, 1985–92.
Petersen RC , Roberts RO , Knopman DS , et al. (2009). Mild cognitive impairment: ten years later. Arch Neurol 66, 1447–55.
Sliwinski M , Lipton RB , Buschke H , Stewart W (1996). The effects of preclinical dementia on estimates of normal cognitive functioning in aging. J Gerontol B Psychol Sci Soc Sci, 51, P217–25.
Storandt M , Grant EA , Miller JP , Morris JC (2006). Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI. Neurology 67, 467–73.
Storandt M , Mintun, MA , Head D , Morris JC (2009). Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition. Arch Neurol 66, 1476–81.
Storandt M , Morris JC (2010). Ascertainment bias in the clinical diagnosis of Alzheimer's disease. Arch Neurol, 67, 1364–9.
Sunderland T , Linker G , Mirza N , et al. (2003). Decreased beta-amyloid1–42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease. JAMA 289, 2094–103.
The American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders (DSM).
Thurstone LL , Thurstone LG (1949). Examiner Manual for the SRA Primary Mental Abilities Test. Chicago, IL, Science Research Associates.
Tuokko H , Garrett DD , Mcdowell I , Silverberg N , Kristjansson B (2003). Cognitive decline in high-functioning older adults: reserve or ascertainment bias? Aging Ment Health, 7, 259–70.
Wechsler D , Stone CP (1973). Manual: Wechsler Memory Scale, New York.
Winblad B , Palmer K , Kivipelto M , et al. (2004). Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256, 240–6.

Reference Title: References and further reading

Reference Type: reference-list

Amarenco P , Bogousslavsky J , Callahan AR , et al. (2006). High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 6, 549–59.
Barba R , Martinez-Espinosa S , Rodriguez-Garcia E , Pondal M , Vivancos J , Del Ser T (2000). Poststroke dementia: clinical features and risk factors. Stroke 7, 1494–501.
Brodaty H , Withall A , Altendorf A , Sachdev PS (2007). Rates of depression at 3 and 15 months poststroke and their relationship with cognitive decline: the Sydney Stroke Study. Am J Geriatr Psychiatry 6, 477–86.
del Ser T , Barba R , Morin MM , et al. (2005). Evolution of cognitive impairment after stroke and risk factors for delayed progression. Stroke 12, 2670–5.
Dubois B , Slachevsky A , Litvan I , Pillon B (2000). The FAB: a Frontal Assessment Battery at bedside. Neurology 11, 1621–6.
Estol CJ , Kase CS (2003). Need for continued use of anticoagulants after intracerebral hemorrhage. Curr Treat Options Cardiovasc Med 3, 201–9.
Firbank MJ , Burton EJ , Barber R , et al. (2006). Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors. Neurobiol Aging, 28(11), 1664–9.
Folstein MF , Folstein SE , McHugh PR (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res, 3, 189–98.
Henon H Durieu I , Guerouaou D , Lebert F , Pasquier F , Leys D (2001). Poststroke dementia: incidence and relationship to prestroke cognitive decline. Neurology 7, 1216–22.
Kavirajan H , Schneider LS (2007). Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials. Lancet Neurol 9, 782–92.
Lyketsos CG , Rosenblatt A , Rabins P (2004). Forgotten frontal lobe syndrome or “Executive Dysfunction Syndrome.” Psychosomatics 3, 247–55.
Opler LA , Ramirez PM , Lee SK (1994). Serotonergic agents and frontal lobe syndrome. J Clin Psychiatry 8, 362–3.
Rao V , Spiro JR , Rosenberg PB , Lee HB , Rosenblatt A , Lyketsos CG (2006). An open-label study of escitalopram (Lexapro) for the treatment of ‘Depression of Alzheimer's disease’ (dAD). Int J Geriatr Psychiatry 3, 273–4.
Reed BR , Mungas DM , Kramer JH , et al. (2007). Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease. Brain, 3, 731–9.
Roman GC Kalaria RN (2006). Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia. Neurobiol Aging 12, 1769–85.
Royall DR , Polk M (1998). Dementias that present with and without posterior cortical features: an important clinical distinction. J Am Geriatr Soc, 1, 98–105.
Sato A , Sato Y , Uchida S (2001). Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain. Int J Dev Neurosci, 3, 327–37.
Srikanth VK , Quinn SJ , Donnan GA , Saling MM , Thrift AG (2006). Long-term cognitive transitions, rates of cognitive change, and predictors of incident dementia in a population-based first-ever stroke cohort. Stroke 10, 2479–83.
Stephens S , Kenny RA , Rowan E , et al. (2004). Neuropsychological characteristics of mild vascular cognitive impairment and dementia after stroke. Int J Geriatr Psychiatry 11, 1053–7.
Tatum WOT , Ross J , Cole AJ (1998). Epileptic pseudodementia. Neurology, 5, 1472–5.
Tham W , Auchus AP , Thong M , et al. (2002). Progression of cognitive impairment after stroke: one year results from a longitudinal study of Singaporean stroke patients. J Neurol Sci 204, 49–52.
Tzourio C , Anderson C , Chapman N , et al. (2003). Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med 9, 1069–75.

Reference Title: References and further reading

Reference Type: reference-list

Arboix A , Martí-Vilalta JL (2009). Lacunar stroke. Exp Rev Neurotherapeutics, 9, 179–96.
Erkinjuntti T , Pantoni L (2000). Subcortical vascular dementia. In Gauthier S , Cummings JL , eds. Yearbook of Alzheimer's Disease and Related Disorders. London: Martin Dunitz; 101–33.
Erkinjuntti, T (1996). Clinicopathological study of vascular dementia. In Prohovnik I , Wade J , Knezevic T , et al., eds. Vascular Dementia: Current Concepts. London: Wiley & Sons.
Grau-Olivares M , Arboix A (2009). Mild cognitive impairment in stroke patients with ischemic cerebral small-vessel disease: a forerunner of vascular dementia? Exp Rev Neurotherapeutics, 9, 1201–17.
Hachinski VC , Lassen NA , Marshall J (1974). Multi-infarct dementia: a cause of mental deterioration in the elderly. Lancet 2, 207–10.
Lenzi GL , Altieri M (2007). Short term evolution as a marker of vascular dementia versus Alzheimer's disease. J Neurol Sci, 257, 182–4.
Leys D , Hénon H , Mackowick-Cordiolani MA , Pasquier F (2005). Postroke dementia. Lancet Neurol, 4, 752–9.
Roman G , Sachdev P , Royall DR , Bullock RA , Orgogozo JM , López-Pousa S , Arizaga R , Wallin A (2004). Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia. J Neurol Sci, 226, 81–7.
Roman GC (2003). Stroke, cognitive decline and vascular dementia: the silent epidemic of the 21st century. Neuroepidem 22, 161–4.
Snowdon DA , Greiner LH , Mortimer JA , Riley KP , Greiner PA , Markersberg WR (1997). Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 277, 813–17.

Reference Title: References and further reading

Reference Type: reference-list

Aarsland D , Brønnick K , Ehrt U , et al. (2007). Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatry 78, 36–42.
Aarsland D , Ballard C , Walker Z , et al. (2009). Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial. Lancet Neurol 8, 613–18.
Bronnick K , Ehrt U , Emre M , et al. (2006). Attentional deficits affect activities of daily living in dementia-associated with Parkinson's disease. J Neurol Neurosurg Psychiatry 77, 1136–42.
Burn DJ , Rowan EN , Allan L , Molloy S , O'Brien J , McKeith IG (2006). Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 77, 585–9.
Emre M , Aarsland D , Albanese A , et al. (2003). Rivastigmine for dementia associated with Parkinson's disease. N Engl J Med 351, 2509–18.
Emre M , Aarsland D , Brown R , et al. (2007). Clinical diagnostic criteria for dementia associated with Parkinson disease. Mov Disord 22, 1689–707.
Ferman TJ , Smith GE , Boeve BF , et al. (2004). DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. Neurology 62, 181–7.
Mamikonyan E , Moberg PJ , Siderowf A , et al. (2009). Mild cognitive impairment is common in Parkinson's disease patients with normal Mini-Mental State Examination (MMSE) scores. Parkinsonism Relat Disord 15, 226–31.
Riedel O , Klotsche J , Spottke A , et al. (2008). Cognitive impairment in 873 patients with idiopathic Parkinson's disease. Results from the German Study on Epidemiology of Parkinson's Disease with Dementia (GEPAD). J Neurol 255, 255–64.
Williams-Gray CH , Foltynie T , Brayne CEG , Robbins TW , Barker RA (2007). Evolution of cognitive dysfunction in an incident Parkinson's disease cohort. Brain 130, 1787–98.

Reference Title: References and further reading

Reference Type: reference-list

Ballard C , Burton E , Barber R , et al. (2004). NINDS AIREN neuroimaging criteria do not distinguish stroke patients with and without dementia. Neurology, 63(6), 983–8.
Ballard C , Sauter M , Scheltens P , et al. (2008). Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study. Curr Med Res Opin, 24(9), 2561–74.
Budson AE, Price BH (2005). Memory dysfunction. N Engl J Med, 352(7), 692–9.
Chui HC , Mack W , Jackson JE , et al. (2000). Clinical criteria for the diagnosis of vascular dementia: a multicenter study of comparability and interrater reliability. Arch Neurol, 57(2), 191–6.
de la Torre JC (2004). Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol, 3(3), 184–90.
Deschaintre Y , Richard F , Ley SD , Pasquier F (2009). Treatment of vascular risk factors is associated with slower decline in Alzheimer's disease. Neurology, 73(9), 674–80.
Dubois B , Feldman HH , Jacova C , et al. (2007). Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 6(8): 734–46.
Dubois B , Touchon J , Portet F , Ousset PJ , Vellas B , Michel B (2002). [“The 5 words”: a simple and sensitive test for the diagnosis of Alzheimer's disease]. Presse Med, 31(36), 1696–9.
Erkinjuntti T , Kurz A , Gauthier S , Bullock R , Lilienfeld S , Damaraju CV (2002). Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. Lancet, 359(9314), 1283–90.
Langa KM , Foster NL , Lawson EBJ (2004). Mixed dementia: emerging concepts and therapeutic implications. JAMA, 292(23), 2901–8.
Leys D , Hénon H , Mackowiak-Cordoliani MA , Pasquier F (2005). Poststroke dementia. Lancet Neurol, 4(11), 752–9.
Moorhouse P , Rockwood K (2008). Vascular cognitive impairment: current concepts and clinical developments. Lancet Neurol, 7(3), 246–55.
Peters R , Beckett N , Forette F , et al. (2008). Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol 7(8), 683–9.
van der Flier WM , van Straaten EC , Barkhof F , et al. (2005). Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study. Stroke, 36(10), 2116–20.
Vermeer SE , Prins ND , den Heijer T , et al. (2003). Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med, 348(13), 1215–22.
Zekry D , Hauw JJ , Gold G (2002). Mixed dementia: epidemiology, diagnosis, and treatment. J Am Geriatr Soc, 50(8), 1431–8.

Reference Title: Further reading

Reference Type: further-reading

Gauthier S , Cummings J , Ballard C , et al. (2010). Management of behavioral problems in Alzheimer's disease. Int Psycho-Geriatrics: in press.
Robert PH , Onyike CU , Leentjens AFG , et al. (2009). Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders. Eur Psychiatry, 24: 98–104.
Waldemar G , Burns A (2009). Alzheimer's Disease. Oxford: Oxford University Press.

Reference Title: References and further reading

Reference Type: reference-list

Benson DF , Davis RJ , Snyder BD (1988). Posterior cortical atrophy. Arch Neurol 45, 789–93.
Dubois B , Feldman H , Jacova C , et al. (2007). Research criteria for the diagnosis of Alzheimer's disease: revisiting of the NINCDS-ADRDA criteria. Lancet Neurol, 6, 734–46.
Habert MO , Horn JF , Sarazin M et al. (2009). Brain perfusion SPECT with an automated quatitative tool can identify prodromal Alzheimer's disease among patients with mild cognitive impairment. Neurobiol Aging, doi:10.1016/j.neurobiolaging.2009.01.013.
Joanette Y , Belleville S , Gely-Nargeot , Ska B , Valdois S (2000). Plurality of patterns of cognitive impairment in normal aging and in dementia. Rev Neurol (Paris), 156, 759–66.
McKhann G , Drachman D , Folstein M et al. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939–44.
Neary D , Snowden JS , Bowen DM et al. (1986). Neuropsychological syndromes in presenile dementia due to cerebral atrophy. J Neurol Neurosurg Psychiatry, 49, 163–74.
Renner JA , Burns JM , Hou CE et al. (2004). Progressive posterior cortical dysfunction: a clinicopathologic series. Neurology, 63, 1175–80.

Reference Title: References and further reading

Reference Type: reference-list

Benson DF , Davis RJ , Snyder BD (1988). Posterior cortical atrophy. Arch Neurol, 45, 789–93.
McMonagle P , Deering F , Berliner Y , Kertesz A (2006). The cognitive profile of posterior cortical atrophy. Neurology, 66, 331–8.
Mendez M , Ghajarania M , Perryman K (2002). Posterior Cortical Atrophy: Clinical Characteristics and Differences Compared to Alzheimer's Disease. Dement Geriatr Cogn Disord, 14, 33–40.
Migliaccio R , Agosta F , Rascovsky K , et al. (2009). Clinical syndromes associated with posterior atrophy: early age at onset AD spectrum. Neurology, 73, 1571–8.
Nestor PJ , Caine D , Fryer TD , et al. (2003). The topography of metabolic deficits in posterior cortical atrophy with FDG-PET. J Neurol Neurosurg Psychiatry, 74, 1521–9.
Renner JA , Burns JM , Hou CE , et al. (2004). Progressive posterior cortical dysfunction: a clinicopathologic series. Neurology, 63, 1175–80.
Rogalski E , Johnson N , Weintraub S , Mesulam M (2008). Increased frequency of learning disability in patients with primary progressive aphasia and their first-degree relatives. Arch Neurol, 65, 244–8.
Schott JM , Ridha BH , Crutch SJ , et al. (2006). Apolipoprotein e genotype modifies the phenotype of Alzheimer disease. Arch Neurol, 63, 155–6.
Tang-Wai DF , Graff-Radford NR , Boeve BF , et al. (2004). Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy. Neurology, 63, 1168–74.
Whitwell JL , Jack CR, Jr. , Kantarci K , et al. (2007). Imaging correlates of posterior cortical atrophy. Neurobiol Aging, 28, 1051–61.

Reference Title: References and further reading

Reference Type: reference-list

Alladi S , Xuereb J , Bak T , et al. (2007). Focal cortical presentations of Alzheimer's disease. Brain, 130, 2636–45.
Attems J Quass M , Jellinger KA , Lintner F (2007). Topographical distribution of cerebral amyloid angiopathy and its effect on cognitive decline are influenced by Alzheimer disease pathology. J Neurol Sci, 257, 49–55.
Battacharji SK , Hutchinson EC , Mccall AJ (1967). The Circle of Willis – the incidence of developmental abnormalities in normal and infarcted brains. Brain, 90, 747–58.
Caulo M , Tampieri D , Brassard R , Guiot CM , Melanson D (2001). Cerebral amyloid angiopathy presenting as nonhemorrhagic diffuse encephalopathy: neuropathologic and neuroradiologic manifestations in one case. Am J Neuroradiol, 22, 1072–6.
De La Torre JC (2004). Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol, 3, 184–90.
Eng JA , Frosch MP , Choi K , Rebeck GW , Greenberg SM (2004). Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann Neurol, 55, 250–6.
Feldman HH , Maia LF , Mackenzie IR , Forster BB , Martzke J , Woolfenden A (2008). Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease. Stroke, 39, 2894–7.
Gorno-Tempini ML , Brambati SM , Ginex V , et al. (2008). The logopenic/phonological variant of primary progressive aphasia. Neurology, 71, 1227–34.
Gorno-Tempini ML , Dronkers NF , Rankin KP , et al. (2004). Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol, 55, 335–46.
Greenberg SM , Finklestein SP , Schaefer PW (1996). Petechial hemorrhages accompanying lobar hemorrhage: detection by gradient-echo MRI. Neurology, 46, 1751–4.
Greenberg SM , Vonsattel JP , Stakes JW , Gruber M , Finklestein SP (1993). The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage. Neurology, 43, 2073–9.
Haacke EM , Delproposto ZS , Chaturvedi S , et al. (2007). Imaging cerebral amyloid angiopathy with susceptibility-weighted imaging. Am J Neuroradiol, 28, 316–17.
Hart RG (2000). What causes intracerebral hemorrhage during warfarin therapy? Neurology, 55, 907–8.
Johnson KA , Gregas M , Becker JA , et al. (2007). Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol, 62, 229–34.
Kinnecom C , Lev MH , Wendell L , et al. (2007). Course of cerebral amyloid angiopathy-related inflammation. Neurology, 68, 1411–16.
Knopman DS , Petersen RC , Edland SD , Cha RH , Rocca WA (2004). The incidence of frontotemporal lobar degeneration in Rochester, Minnesota, 1990 through 1994. Neurology, 62, 506–8.
Knudsen KA , Rosand J , Karluk D , Greenberg SM (2001). Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology, 56, 537–9.
Levy E , Carman MD , Fernandez-Madrid IJ , et al. (1990). Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science, 248, 1124–6.
Maia LF , Mackenzie IR , Feldman HH (2007). Clinical phenotypes of Cerebral Amyloid Angiopathy. J Neurol Sci, 257, 23–30.
Mesulam M , Wicklund A , Johnson N , et al. (2008). Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann Neurol, 63, 709–19.
Migliaccio R , Agosta F , Rascovsky K , et al. (2009). Clinical syndromes associated with posterior atrophy: early age at onset AD spectrum. Neurology, 73, 1571–8.
Neary D , Snowden JS , Gustafson L , et al. (1998). Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology, 51, 1546–54.
Oh U , Gupta R , Krakauer JW , et al. (2004). Reversible leukoencephalopathy associated with cerebral amyloid angiopathy. Neurology, 62, 494–7.
Ohshima T , Endo T , Nukui H , Ikeda S , Allsop D , Onaya T (1990). Cerebral amyloid angiopathy as a cause of subarachnoid hemorrhage. Stroke, 21, 480–3.
Pantoni L , Garcia JH (1997). Cognitive impairment and cellular/vascular changes in the cerebral white matter. Ann NY Acad Sci, 826, 92–102.
Rabinovici GD , Jagust WJ , Furst AJ , et al. (2008). Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia. Ann Neurol, 64, 388–401.
Snowdon DA , Greiner LH , Mortimer JA , Riley KP , Greiner PA , Markesbery WR (1997). Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. J Am Med Assoc., 277, 813–17.
Thal DR , Griffin WS , De Vos RA , Ghebremedhin E (2008). Cerebral amyloid angiopathy and its relationship to Alzheimer's disease. Acta Neuropathol, 115, 599–609.
Vagal AS , Leach JL , Fernandez-Ulloa M , Zuccarello M (2009). The acetazolamide challenge: techniques and applications in the evaluation of chronic cerebral ischemia. Am J Neuroradiol, 30, 876–84.
Weller RO , Boche D , Nicoll JA (2009). Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy. Acta Neuropathol, 118, 87–102.

Reference Title: References and further reading

Reference Type: reference-list

Hodges JR , Mitchell J , Dawson K , et al. (2009). Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases. Brain, 132, 2734–46.
Hodges JR , Patterson K (2007). Semantic dementia: a unique clinicopathological syndrome. Lancet Neurol, 6, 1004–14.
Johnson JK , Diehl J , Mendez MF , et al. (2005). Frontotemporal lobar degeneration: demographic characteristics of 353 patients. Arch Neurol, 62, 925–30.
Jokel R , Rochon E , Leonard C (2006). Treating anomia in semantic dementia: improvement, maintenance, or both? Neuropsychol Rehabil, 16, 241–56.
Mesulam MM (2007). Primary progressive aphasia: a 25-year retrospective. Alzheimer Dis Assoc Disord, 21, S8–S11.
Neary D , Snowden JS , Gustafson L , et al. (1998). Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology, 51, 1546–54.
Rohrer JD , Guerreiro R , Vandrovcova J , et al. (2009). The heritability and genetics of frontotemporal lobar degeneration. Neurology, 73, 1451–6.
Snowden J , Goulding PJ , Neary D (1989). Semantic Dementia: a form of circumscribed cerebral atrophy. Behav Neurol, 2, 167–82.
Snowden J , Neary D , Mann D (2007). Frontotemporal lobar degeneration: clinical and pathological relationships. Acta Neuropathol, 114, 31–8.
Thompson SA , Patterson K , Hodges JR (2003). Left/right asymmetry of atrophy in semantic dementia: behavioral-cognitive implications. Neurology, 61, 1196–203.

Reference Title: References and further reading

Reference Type: reference-list

Ayala YM , Pantano S , D'Ambrogio A , et al. (2005). Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function. J Mol Biol, 348, 575–88.
Brooks BR , Miller RG , Swash M , Munsat TL (2000). El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord, 1, 293–9.
Chaudhuri KR , Crump S , al-Sarraj S , Anderson V , Cavanagh J , Leigh PN (1995). The validation of El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis: a clinicopathological study. J Neurol Sci, 129, Suppl:11–12.
Forman MS , Trojanowski JQ , Lee VM (2007). TDP-43: a novel neurodegenerative proteinopathy. Curr Opin Neurobiol, 17, 548–55.
Lomen-Hoerth C (2004). Characterization of amyotrophic lateral sclerosis and frontotemporal dementia. Dement Geriatr Cogn Disord, 17, 337–41.
Lund & Manchester groups (1994). Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups. J Neurol Neurosurg Psychiatry, 57, 416–18.
Mackenzie IR (2007). The neuropathology of FTD associated With ALS. Alzheimer Dis Assoc Disord, 21, S44–9.
Mackenzie IR , Neumann M , Bigio EH , et al. (2009). Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol 117, 15–18.
McKhann GM , Albert MS , Grossman M , Miller B , Dickson D , Trojanowski JQ (2001). Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease. Arch Neurol, 58, 1803–9.
Neary D , Snowden J , Mann D (2005). Frontotemporal dementia. Lancet Neurol, 4, 771–80.
Neary D , Snowden JS , Gustafson L , et al. (1998). Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology, 51, 1546–54.
Neumann M , Sampathu DM , Kwong LK (2006). Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science, 314, 130–3.
Olney RK , Murphy J , Forshew D , et al. (2005). The effects of executive and behavioral dysfunction on the course of ALS. Neurology, 65, 1774–7.
Ringholz GM , Appel SH , Bradshaw M , Cooke NA , Mosnik DM , Schulz PE (2005). Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology, 65, 586–90.
Strong MJ (2008). The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis. Amyotroph Lateral Scler, 9, 323–38.
Wang HY , Wang IF , Bose J , Shen CK (2004). Structural diversity and functional implications of the eukaryotic TDP gene family. Genomics, 83, 130–9.

Reference Title: References and further reading

Reference Type: reference-list

Amici S , Gorno-Tempini ML , Ogar JM , Dronkers NF , Miller BL (2006). An overview on Primary Progressive Aphasia and its variants. Behav Neurol, 17, 77–87.
Boeve BF , Lang AE , Litvan I (2003). Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia. Ann Neurol, 54, Suppl 5, S15–19.
Knibb JA , Xuereb JH , Patterson K , Hodges JR (2006). Clinical and pathological characterization of progressive aphasia. Ann Neurol, 59, 156–65.
Mesulam MM (2007). Primary progressive aphasia: a 25-year retrospective. Alzheimer Dis Assoc Disord, 21, S8–S11.
Neary D , Snowden JS , Gustafson L , et al. (1998). Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology, 51, 1546–54.
Nestor PJ , Graham NL , Fryer TD , Williams GB , Patterson K , Hodges JR (2003). Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula. Brain, 126, 2406–18.
Ogar JM , Gorno-Tempini ML (2009). The Behavioral Neurology of Dementia, Cambridge, UK, New York: Cambridge University Press.
Reed DA , Johnson NA , Thompson C , Weintraub S , Mesulam MM (2004). A clinical trial of bromocriptine for treatment of primary progressive aphasia. Ann Neurol, 56, 750.
Rosen HJ , Allison SC , Ogar JM , et al. (2006). Behavioral features in semantic dementia vs other forms of progressive aphasias. Neurology, 67, 1752–6.
Vossel KA , Miller BL (2008). New approaches to the treatment of frontotemporal lobar degeneration. Curr Opin Neurol, 21, 708–16.

Reference Title: References and further reading

Reference Type: reference-list

Arai T , Hasegawa M , Nonoka T , et al. (2010). Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy. Neuropathology, 30(2), 170–81.
Behrens MI , Mukherjee O , Tu PH , et al. (2007). Neuropathologic heterogeneity in HDDD1: a Familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation. Alzheimer Dis Assoc Disord, 21, 1–7.
Boeve BF , Baker M , Dickson DW , et al. (2006). Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study. Brain, 129, 3103–14.
Bruni AC , Momeni P , Bernardi L , et al. (2007). Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation. Neurology, 69, 140–7.
Gass J , Cannon A , Mackenzie IR , et al. (2006). Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. Hum Mol Genet, 15, 2988–3001.
Geser F , Martinez-Lage M , Kwong LK , Lee VM , Trojanowski JQ (2009). Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases. J Neurol, 256, 1205–14.
Josephs KA , Ahmed Z , Katsuse O , et al. (2007). Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations. J Neuropathol Exp Neurol, 66, 142–51.
Kelley BJ , Haidar W , Boeve BF , et al. (2009). Prominent phenotypic variability associated with mutations in Progranulin. Neurobiol Aging, 30, 739–51.
Kwiatkowski TJ, Jr , Bosco DA , Leclerc AL , et al. (2009). Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science, 323, 1205–8.
Lagier-Tourenne C , Cleveland DW (2009). Rethinking ALS: the FUS about TDP-43. Cell, 136, 1001–4.
Mackenzie IR , Baker M , Pickering-Brown S , et al. (2006). The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene. Brain, 129, 3081–90.
Morita M , Al-Chalabi A , Andersen PM , et al. (2006). A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia. Neurology, 66, 839–44.
Neary D , Snowden J , Mann D (2005). Frontotemporal dementia. Lancet Neurol, 4, 771–80.
Neumann M , Rademakers R , Roeber S , Baker M , Kretzschmar HA , Mackenzie IR (2009). A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain, 132, 2922–31.
Nishihira Y , Tan CF , Toyoshima Y , et al. (2009). Sporadic amyotrophic lateral sclerosis: widespread multisystem degeneration with TDP-43 pathology in a patient after long-term survival on a respirator. Neuropathology, 29, 689–96.
Schymick JC , Yang Y , Andersen PM , et al. (2007). Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. J Neurol Neurosurg Psychiatry, 78, 754–6.
Valdmanis PN , Dupre N , Bouchard JP , et al. (2007). Three families with amyotrophic lateral sclerosis and frontotemporal dementia with evidence of linkage to chromosome 9p. Arch Neurol, 64, 240–5.
Vance C , Al-Chalabi A , Ruddy D , et al. (2006). Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2–21.3. Brain, 129, 868–76.
Vance C , Rogelj B , Hortobagyi T , et al. (2009). Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science, 323, 1208–11.
Wider C , Uitti RJ , Wszolek ZK , et al. (2008). Progranulin gene mutation with an unusual clinical and neuropathologic presentation. Mov Disord, 23, 1168–73.

Reference Title: References and further reading

Reference Type: reference-list

Cairns NJ , Bigio EH , Mackenzie IR , et al. (2007). Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol (Berl), 114(1), 5–22.
Graham A , Davies R , Xuereb R , et al. (2005). Pathologically proven frontotemporal dementia presenting with severe amnesia. Brain, 128, 597–605.
Gregory C , Lough S , Stone V , et al. (2002). Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications. Brain, 125, 752–64.
Hodges JR , ed. (2007). Frontotemporal Dementia Syndromes. Cambridge, UK: Cambridge University Press.
Keane J , Calder AJ , Hodges JR , Young AW (2002). Face and emotion processing in frontal variant frontotemporal dementia. Neuropsychologia, 40, 655–65.
Kipps CM , Knibb, JA , Hodges JR (2007). Clinical presentations of frontotemporal dementia. In Hodges JR. , ed. Frontotemporal Dementia Syndromes. Cambridge, UK: Cambridge University Press.
Lavenu I , Pasquier F , Lebert F , Petit H , van der Linden M (1999). Perception of emotion in frontotemporal dementia and Alzheimer disease. Alzheimer Disease and Associated Disorders, 13, 96–101.
Lough S , Kipps CM , Treise C , Watson P , Blair JR , Hodges JR (2006). Social reasoning, emotion and empathy in frontotemporal dementia. Neuropsychologia, 44, 950–8.
McKhann GM , Albert MS , Grossman M , Miller B , Dickson D , Trojanowski JQ (2001). Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease. Arch Neurol, 58, 1803–9.
Pijnenburg YAL , Gillissen F , Jonker C , Scheltens P (2004). Initial complaints in frontotemporal lobar degeneration. Dementia and Geriatric Cognitive Disorders, 17(4), 302–6.
Rosen HJ , Allison SC , Schauer GF , Gorno-Tempini ML , Weiner MW , Miller BL (2005). Neuroanatomical correlates of behavioural disorders in dementia. Brain, 128, 2612–25.
Royall DR , Mahurin RK , Gray KF (1992). Bedside assessment of executive cognitive impairment: the executive interview. J Am Geriatr Soc, 40, 1221–6.
Snowden JS , Neary D , Mann D (1996). Fronto-Temporal Lobar Degeneration: Fronto-Temporal Dementia, Progressive Aphasia, Semantic Dementia. New York: Churchill Livingstone.
Snowden JS , Gibbons ZC , Blackshaw A , et al. (2003). Social cognition in frontotemporal dementia and Huntington's disease. Neuropsychologia, 41(6), 688–701.
Sprengelmeyer R , Young, AW , Calder AJ , et al. (1996). Loss of disgust. Perception of faces and emotions in Huntington's disease. Brain, 119, 1647–65.
Stokholm J , Vogel A , Gade A , Waldemar G (2005). The Executive Interview (EXIT25) as a screening test for executive dysfunction in patients with mild dementia. J Am Geriatr Soc, 53 (9), 1577–81.

Reference Title: References and further reading

Reference Type: reference-list

Boeve BF , Lang AE , Litvan I (2003). Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia. Ann Neurol, 54, S15–19.
Graham NL , Zeman A , Young AW , et al. (1999). Dyspraxia in a patient with corticobasal degeneration: the role of visual and tactile inputs to action. J Neurol Neurosurg Psychiatry, 67, 334–44.
Graham NL , Bak TH , Hodges JR (2003). Corticobasal degeneration as a cognitive disorder. Mov Disord, 18, 1224–32.
Hanna-Pladdy B , Heilman KM , Foundas AL (2003). Ecological implications of ideomotor apraxia: evidence from physical activities of daily living. Neurology 60, 487–90.
Jacobs DH , Adair JC , Macauley B , et al. (1999). Apraxia in corticobasal degeneration. Brain Cogn, 40, 336–54.
Kertesz A , Martinez-Lage P , Davidson W , et al. (2000). The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. Neurology, 55, 1368–75.
Leiguarda R , Lees AJ , Merello M , et al. (1994). The nature of apraxia in corticobasal degeneration. J Neurol Neurosurg Psychiatry, 57, 455–9.
Petreska B , Adriani M , Blanke O , et al. (2007). Apraxia: a review. Prog Brain Res, 164, 61–83.
Stamenova V , Roy EA , Black SE (2009). A model-based approach to understanding apraxia in corticobasal syndrome. Neuropsychol Rev, 19, 47–63.
Wadia PM , Lang AE (2007). The many faces of corticobasal degeneration. Parkinsonism Relat Disord, 13 Suppl 3:S336–40.

Reference Title: Further reading

Reference Type: further-reading

Cramer C , Haan MN , Galea S , Langa KM , Kalbfleisch JD (2008). Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study. Neurology, 71, 344–50.
Cukierman-Yaffe T , Gerstein HC , Williamson JD , et al. for the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) investigators (2009). Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors. Diabetes Care, 32, 221–6.
Debette S , Beiser A , Decarli C , et al. (2010). Association of MRI Markers of Vascular Brain Injury With Incident Stroke, Mild Cognitive Impairment, Dementia, and Mortality. The Framingham Offspring Study. Stroke, Feb 18. [Epub ahead of print]
Gorelick PB , Bowler JV (2010). Advances in vascular cognitive impairment. Stroke, 41(2), e93–e98.
Kazui H , Ishii R , Yoshida T , et al. (2009). Neuroimaging studies in patients with Charles Bonnet Syndrome. Psychogeriatrics, 9(2), 77–84.
Mendez MF , Shapira JS , McMurtray A , Licht E (2007). Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia. Am J Geriatr Psychiatry, 15(1), 84–7.
Peters R , Beckett N , Forette F , et al. (2008). Incident dementia and blood pressure lowering in the HYpertension in the Very Elderly Trial COGnitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol, 7, 683–9.

Reference Title: References and further reading

Reference Type: reference-list

Angelelli P , Paolucci S , Bivona U , et al. (2004). Development of neuropsychiatric symptoms in poststroke patients: a cross-sectional study. Acta Psychiatr Scand, 110(1), 55–63.
Ballard C , Neill D , O'Brien J , McKeith IG , Ince P , Perry R (2000). Anxiety, depression and psychosis in vascular dementia: prevalence and associations. J Affect Disord, 59(2), 97–106.
Benito-Leon J , Dominguez J (1998). Kluver–Bucy syndrome in late delayed postirradiation encephalopathy. J Neurol, 245(6–7), 325–6.
Binetti G , Bianchetti A , Padovani A , Lenzi G , De Leo D , Trabucchi M (1993). Delusions in Alzheimer's disease and multi-infarct dementia. Acta Neurol Scand, 88(1), 5–9.
Blessed G , Tomlinson BE , Roth M (1968). The association between quantitative measures of dementia and senile changes in the cerebral white matter of elderly subjects. Br J Psychiat, 114, 797–811.
Carroll BT , Goforth HW , Raimonde LA (2001). Partial Kluver–Bucy syndrome: two cases. CNS Spectr, 6(4), 329–32.
Chou CL , Lin YJ , Sheu YL , Lin CJ , Hseuh IH (2008). Persistent Kluver–Bucy syndrome after bilateral temporal lobe infarction. Acta Neurol Taiwan, 17(3), 199–202.
Cummings JL (1993). Frontal-subcortical circuits and human behavior. Arch Neurol, 50, 873–80.
Folstein MF , Folstein SE , McHugh PR (1975). Mini-mental state: a practical method grading the cognitive state of patients for the clinician. Psychiat Research, 12, 189–98.
Guidotti TL , Charness ME , Lamon JM (1979). Acute intermittent porphyria and the Kluver–Bucy syndrome. Johns Hopkins Med J, 145(6), 233–5.
Hachinski VC , Iliff LD , Zihka E , et al. (1975). Cerebral blood flow in dementia. Arch Neurol, 32, 632–7.
Hamilton M (1960). A rating scale for depression. J Neurol , Neurosurg, Psychiatry, 23, 56–62.
Hayman LA , Rexer JL , Pavol MA , Strite D , Meyers CA (1998). Kluver–Bucy syndrome after bilateral selective damage of amygdala and its cortical connections. J Neuropsychiatry Clin Neurosci, 10(3), 354–8.
Janati A (1985). Kluver–Bucy syndrome in Huntington's chorea. J Nerv Ment Dis, 173(10), 632–5.
Jellinger KA (2002). The pathology of ischemic–vascular dementia: an update. J Neurol Sci, 203–204, 153–7.
Kile SJ , Ellis WG , Olichney JM , Farias S , DeCarli C (2009). Alzheimer abnormalities of the amygdala with Kluver–Bucy syndrome symptoms: an amygdaloid variant of Alzheimer disease. Arch Neurol, 66(1), 125–9.
Kitabayashi Y , Narumoto J , Otakara C , Hyungin C , Fukui K , Yamada K (2006). Schizophrenia-like psychosis following right putaminal infarction. J Neuropsychiatry Clin Neurosci, 18(4), 561–2.
Kluver H , Bucy PC (1937). “Psychic blindness” and other symptoms following bilateral temporal lobectomy in rhesus monkeys. Am J Physiol, 119, 352–3.
Leesch W , Fischer I , Staudinger R , Miller DC , Sathe S (2009). Primary cerebral Whipple disease presenting as Kluver–Bucy syndrome. Arch Neurol, 66(1), 130–1.
Levine DN , Finklestein S (1982). Delayed psychosis after right temporoparietal stroke or trauma: relation to epilepsy. Neurology, 32(3), 267–73.
Lilly R , Cummings JL , Benson DF , Frankel M (1983). The human Kluver–Bucy syndrome. Neurology, 33(9), 1141–5.
Looi JC , Tatham V , Kumar R , et al. (2009). Caudate nucleus volumes in stroke and vascular dementia. Psychiatry Res, 174(1), 67–75.
Lopez OL , Becker JT , Klunk W , Dekosky S (1995). The nature of behavioral disorders in human Kluver–Bucy syndrome. Neuropsychiat Neuropsychol Behav Neurol, 8(3), 215–21.
Lopez OL , Smith G , Becker JT , Meltzer CC , DeKosky ST (2001). The psychotic phenomenon in probable Alzheimer's disease: a positron emission tomographic study. J Neuropsychiatry Clin Neurosci, 13, 50–5.
Lopez OL , Becker JT , Sweet RA , et al. (2003). Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease. J Neuropsychiatry Clin Neurosci, 15(3), 346–53.
Lopez OL , Kuller LH , Becker JT (2004). Diagnosis, risk factors, and treatment of vascular dementia. Curr Neurol Neurosci Rep, 4(5), 358–67.
Lyketsos CG , Lopez O , Jones B , Fitzpatrick AL , Breitner J , DeKosky S (2002). Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. J Am Med Assoc, 288(12), 1475–83.
Mahler ME , Cummings JL (1991). Behavioral neurology of multi-infarct dementia. Alzheimer Dis Assoc Disord, 5(2), 122–30.
Mattis S (1976). Mental status examination for organic mental syndrome in the elderly patient. In Bellak L , Karuso TB , eds. Geriatric Psychiatry. New York: Grune & Stratton.
Mielke R , Herholz K , Grond M , Kessler J , Heiss W-D (1992). Severity of vascular dementia is related to volume of metabolically impaired tissue. Arch Neurol, 49, 909–13.
Muller A , Baumgartner RW , Rohrenbach C , Regard M (1999). Persistent Kluver-Bucy syndrome after bilateral thalamic infarction. Neuropsychiatry Neuropsychol Behav Neurol, 12(2), 136–9.
Nishio Y , Ishii K , Kazui H , Hosokai Y , Mori E (2007). Frontal-lobe syndrome and psychosis after damage to the brainstem dopaminergic nuclei. J Neurol Sci, 260(1–2), 271–4.
Powers JM , Schaumburg HH , Gaffney CL (1980). Kluver–Bucy syndrome caused by adreno-leukodystrophy. Neurology, 30(11), 1231–2.
Robinson RG , Parikh RM , Lipsey JR , Starkstein SE , Price TR (1993). Pathological laughing and crying following stroke: validation of a measurement scale and a double-blind treatment study. Am J Psychiatry, 150(2), 286–93.
Roman GC (1985). The identity of lacunar dementia and Binswanger disease. Med Hypotheses, 16(4), 389–91.
Schuff N , Matsumoto S , Kmiecik J , et al. (2009). Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging. Alzheimer's Dement, 5(6), 454–62.
Shoji H , Teramoto H , Satowa S , Satowa H , Narita Y (1979). Partial Kluver–Bucy Syndrome following probably herpes simplex encephalitis. J Neurol, 221(3), 163–7.
Staekenborg SS , Su T , van Straaten EC , et al. (2009). Behavioural and psychological symptoms in vascular dementia; differences between small and large vessel disease. J Neurol Neurosurg Psychiatry, 81(5), 547–51.
Starkstein SE , Robinson RG , Berthier ML , Price TR (1988). Depressive disorders following posterior circulation as compared with middle cerebral artery infarcts. Brain, 111, 375–87.
Starkstein SE , Migliorelli R , Teson A , et al. (1995). Prevalence and clinical correlates of pathological affective display in Alzheimer's disease. J Neurol, Neurosurg, Psychiatry, 59(1), 55–60.
Steffens DC , Maytan M , Helms MJ , Plassman BL (2005). Prevalence and clinical correlates of neuropsychiatric symptoms in dementia. Am J Alzheimer's Dis Other Demen, 20(6), 367–73.
Terzian H , Ore GD (1955). Syndrome of Kluver and Bucy; reproduced in man by bilateral removal of the temporal lobes. Neurology, 5(6), 373–80.
Thompson C , Brodaty H , Trollor J , Sachdev P (2009). Behavioral and psychological symptoms associated with dementia subtype and severity. Int Psychogeriatr, 1–6.
White L , Petrovich H , Hardman J , et al. (2002). Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann NY Acad Sci, 977, 9–23.

Reference Title: References and further reading

Reference Type: reference-list

Aarsland D , Mosimann UP , McKeith IG (2004). Role of cholinesterase inhibitors in Parkinson's disease and dementia with Lewy bodies. J Geriatr Psychiatry Neurol, 17, 164–71.
Ballard CG , Jacoby R , Del Ser T , et al. (2004). Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies. Am J Psychiatry, 161, 843–9.
Beyer MK , Larsen JP , Aarsland D (2007). Gray matter atrophy in Parkinson disease with dementia and dementia with Lewy bodies. Neurology, 69, 747–54.
Kaufer DI , Cummings JL , Ketchel P , et al. (2000). Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci, 12, 233–9.
McKeith I , Del Ser T , Spano P , et al. (2000). Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet, 356, 2031–6.
McKeith IG , Dickson DW , Lowe J , et al. (2005). Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology, 65, 1863–72.
Metzler-Baddeley C (2007). A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer's disease and Parkinson's disease with dementia. Cortex, 43, 583–600.
Molloy SA , Rowan EN , O'Brien JT , McKeith IG , Wesnes K , Burn DJ (2006). Effect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry, 77, 1323–8.
O'Brien JT , McKeith IG , Walker Z , et al. (2009). Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies. Br J Psychiatry, 194, 34–9.

Reference Title: References and further reading

Reference Type: reference-list

Bisschops RH , Klijn CJ , Kappelle LJ , et al. (2003). Collateral flow and ischemic brain lesions in patients with unilateral carotid artery occlusion. Neurology, 60, 1435–41.
Corey-Bloom J , Sabbagh MN , Bondi MW , et al. (1997). Hippocampal sclerosis contributes to dementia in the elderly. Neurology, 48, 154–60.
Crystal HA , Dickson DW , Sliwinski MJ , et al. (1993). Pathological markers associated with normal aging and dementia in the elderly. Ann Neurol, 34, 566–73.
Dickson DW , Davies P , Bevona C , et al. (1994). Hippocampal sclerosis: a common pathological feature of dementia in very old (greater than 80 years of age) humans. Acta Neuropathol, 88, 212–21.
Hossain M , Sathe T , Fazio V , et al. (2009). Tobacco smoke: a critical etiological factor for vascular impairment at the blood–brain barrier. Brain Res, 1287, 192–205.
Leverenz JB , Agustin CM , Tsuang D , et al. (2002). Clinical and neuropathological characteristics of hippocampal sclerosis. Arch Neurol, 59, 1099–106.
Miklossy J (2003). Cerebral hypoperfusion induces cortical watershed microinfarcts which may further aggravate cognitive decline in Alzheimer's disease. Neurol Res, 25, 605–10.
Momjian-Mayor I , Baron JC (2005). The pathophysiology of watershed infarction in internal carotid artery disease: review of cerebral perfusion studies. Stroke, 36, 567–77.
Moody DM , Bell MA , Challa VR (1990). Features of cerebral vascular pattern that predict vulnerability to perfusion or oxygenation deficiency: an anatomical study. Am J Neuroradiol, 11, 431–9.
Pantoni L , Garcia JH , Gutierrez JA (1996). Cerebral white matter is highly vulnerable to ischemia. Stroke, 27, 1641–7.
Román GC (2004). Brain hypoperfusion: a critical factor in vascular dementia. Neurological Research, 26, 454–8.
Román GC , Tatemichi TK , Erkinjuntti T , et al. (1993). Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology, 43, 250–60.
Schomer DF , Marks MP , Steinberg GK , et al. (1994). The anatomy of the posterior communicating artery as a risk factor for ischemic cerebral infarction. N Engl J Med, 330, 1565–70.
Suter OC , Sunthorn T , Kraftsik R , et al. (2002). Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease. Stroke, 33, 1986–92.
Vinters HV , Ellis WG , Zarow C , et al. (2000). Neuropathologic substrates of ischemic vascular dementia. J Neuropathol Exp Neurol, 59, 931–45.

Reference Title: References and further reading

Reference Type: reference-list

Barrett AM (2005). Is it Alzheimer's disease or something else? 10 disorders that may feature impaired memory and cognition. Postgrad Med, 117(5), 47–53.
Dubois B , HH Feldman , Jacova C , et al. (2007). Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol, 6(8), 734–46.
Fujimoto H , Imaizumi T , Yoshida H , et al. (2001). Neurosyphilis showing transient global amnesia-like attacks and magnetic resonance imaging abnormalities mainly in the limbic system. Intern Med, 40(5), 439–42.
Gurses C , Kurtuncu M , Jirsch J , et al. (2007). Neurosyphilis presenting with status epilepticus. Epileptic Disord, 9(1), 51–6.
Kodama K , Okada S , Komatsu N , et al. (2000). Relationship between MRI findings and prognosis for patients with general paresis. J Neuropsychiatry Clin Neurosci, 12(2), 246–50.
Kohler CG , Ances BM , Coleman AR , et al. (2000). Marchiafava-Bignami disease: literature review and case report. Neuropsychiatry Neuropsychol Behav Neurol, 13(1), 67–76.
Lee CH , Lin WC , et al. (2009). Initially unrecognized dementia in a young man with neurosyphilis. Neurologist, 15(2), 95–7.
Mehrabian S , Raycheva MR , Petrova E , et al. (2009). Neurosyphilis presenting with dementia, chronic chorioretinitis and adverse reactions to treatment: a case report. Cases J, 2, 8334.
van Eijsden P , Veldink JH , Linn FH , et al. (2008). Progressive dementia and mesiotemporal atrophy on brain MRI: neurosyphilis mimicking pre-senile Alzheimer's disease? Eur J Neurol, 15(2), e14–5.
Wahlund LO , Julin P , Johansson S-E , et al. (2000). Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging in dementia: a comparative study. J Neurol Neurosurg Psychiatry, 69(5), 630–5.
Zamboni G , Huey ED , Krueger F , et al. (2008). Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. Neurology, 71(10), 736–42.

Reference Title: References and further reading

Reference Type: reference-list

Angstadt JD , Bodziner RA , (2005). Peripheral polyneuropathy from thiamine deficiency following laparoscopic Roux-en-Y gastric bypass. Obes Surg, 15(6), 890–2.
Bertrand A , Brandel JP , Grignon Y , et al. (2009). Wernicke encephalopathy and Creutzfeldt–Jakob disease. J Neurol, 256(6), 904–9.
Collie DA , Summers DM , Sellar RJ , et al. (2003). Diagnosing variant Creutzfeldt–Jakob disease with the Pulvinar sign: MR imaging findings in 86 neuropathologically confirmed cases. Am J Neuroradiol, 24(8), 1560–9.
Dallal RM (2006). Wernicke encephalopathy after bariatric surgery: losing more than just weight. Neurology, 66(11), 1786.
Donnino MW , Vega J , Miller J , Walsh M (2007). Myths and misconceptions of Wernicke's encephalopathy: what every emergency physician should know. Ann Emerg Med, 50(6), 715–21.
Doss A , Mahad D , Romanowski CAJ (2003). Wernicke encephalopathy: unusual findings in nonalcoholic patients. J Comput Assist Tomogr, 27(2), 235–40.
Fandiño JN , Benchimol AK , Fandiño LN , Barroso FL , Coutinho WF , Appolinário JC (2005). Eating avoidance disorder and Wernicke–Korsakoff syndrome following gastric bypass: an under-diagnosed association. Obes Surg, 15(8), 1207–10.
Geschwind MD , Shu H , Haman A , Sejvar JJ , Miller BL (2008). Rapidly progressive dementia. Ann Neurol, 64(1), 97–108.
Haïk S , Brandel JP , Oppenheim C , et al. (2002). Sporadic CJD clinically mimicking variant CJD with bilateral increased signal in the Pulvinar. Neurology, 58(1), 148–9.
Heinemann U , Krasnianski A , Meissner B , et al. (2007). Creutzfeldt–Jakob disease in germany: a prospective 12-year surveillance. Brain, 130(5), 1350–9.
Karaiskos I , Katsarolis I , Stefanis L (2008). Severe dysphagia as the presenting symptom of Wernicke–Korsakoff syndrome in a non-alcoholic man. Neurol Sci, 29(1), 45–6.
Kelley BJ , Boeve BF , Josephs KA (2009). Rapidly progressive young-onset dementia. Cogn Behav Neurol, 22(1), 22–7.
Koike H , Ito S , Morozumi S , et al. (2008). Rapidly developing weakness mimicking Guillain-Barré syndrome in Beriberi neuropathy: two case reports. Nutrition, 24(7–8), 776–80.
Krasnianski A , Schulz-Schaeffer WJ , Kallenberg K , et al. (2006). Clinical findings and diagnostic tests in the MV2 subtype of sporadic CJD. Brain, 129(9), 2288–96.
Makarewicz W , Kaska L , Kobiela J , et al. (2007). Wernicke's syndrome after sleeve gastrectomy. Obes Surg, 17(5), 704–6.
Nolli M , Barbieri A , Pinna C , Pasetto A , Nicosia F (2005). Wernicke's encephalopathy in a malnourished surgical patient: clinical features and magnetic resonance imaging. Acta Anaesthesiol Scand, 49(10), 1566–70.
Pearce JMS (2008). Wernicke–Korsakoff encephalopathy. Eur Neurol, 59(1–2), 101–4.
Sechi G (2008). Prognosis and therapy of Wernicke's encephalopathy after obesity surgery. Am J Gastroenterol, 103(12), 3219.
Sechi G , Serra A (2007). Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol, 6(5), 442–55.
Singh S , Kumar A (2007). Wernicke encephalopathy after obesity surgery: a systematic review. Neurology, 68(11), 807–11.
Summers DM , Collie DA , Zeidler M , Will RG (2004). The pulvinar sign in variant Creutzfeldt–Jakob disease. Arch Neurol, 61(3), 446–7.
Tschampa HJ , Zerr I , Urbach H (2007). Radiological assessment of Creutzfeldt–Jakob disease. Eur Radiol, 17(5), 1200–11.
Walker FO (2007). Huntington's disease. Lancet, 369(9557), 218–28.
Walker J , Kepner A (2009). Wernicke's encephalopathy presenting as acute psychosis after gastric bypass. J Emerg Med,
Weidauer S , Nichtweiss M , Lanfermann H , Zanella FE (2003). Wernicke encephalopathy: MR findings and clinical presentation. Eur Radiol, 13(5), 1001–9.
Will RG , Ironside JW , Zeidler M , et al. (1996). A new variant of Creutzfeldt–Jakob disease in the UK. Lancet, 347(9006), 921–5.
Zeidler M , Johnstone EC , Bamber RW , et al. (1997a). New variant Creutzfeldt–Jakob disease: psychiatric features. Lancet, 350(9082), 908–10.
Zeidler M , Stewart GE , Barraclough CR , et al. (1997b). New variant creutzfeldt-jakob disease: neurological features and diagnostic tests. Lancet, 350(9082), 903–7.
Zeidler M , Sellar RJ , Collie DA , et al. (2000). The pulvinar sign on magnetic resonance imaging in variant Creutzfeldt–Jakob disease. Lancet, 355(9213), 1412–18.

Reference Title: References and further reading

Reference Type: reference-list

Antinori A , Arendt G , Becker JT , et al. (2007). Updated research nosology for HIV-associated neurocognitive disorders. Neurology, 69, 1789–99.
Brew BJ (2001). AIDS dementia complex. In HIV Neurology. New York: Oxford University Press, pp. 74–7.
Brew BJ , Letendre SL (2008). Biomarkers of HIV related central nervous system disease. Int Rev Psychiatry, 20, 73–88.
Ellis RJ , Calero P , Stockin MD (2009). HIV infection and the central nervous system: a primer. Neuropsychol Rev, 19, 144–51.
Letendre SL , McCutchan JA , Childers ME , et al. (2004). Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders. Ann Neurol, 56, 416–23.
McArthur JC , Brew BJ , Nath A (2005). Neurological complications of HIV infection. Lancet Neurol, 4, 543–55.
Price RW , Brew BJ (1988). The AIDS dementia complex. J Infect Dis, 158, 1079–83.
Robertson KR , Smurzynski M , Parsons TD , et al. (2007). The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS, 21, 1915–21.
Thurnher MM , Donovan Post MJ (2008). The uses of structural neuroimaging in the brain in HIV-1 infected patients. In The Spectrum of Neuro-AIDS Disorders: Pathophysiology, Diagnosis and Treatment. Washington: ASM Press, pp. 247–72.

Reference Title: References and further reading

Reference Type: reference-list

Arata J , Takashima H , Hirano R , et al. (2006). Early clinical signs and imaging findings in Gerstmann–Sträussler-Scheinker syndrome (Pro102Leu). Neurology, 66, 1672–8.
Hsiao K , Baker HF , Crow TJ , et al. (1989). Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome. Nature, 338, 342–5.
Robitaille Y , Wood P , Etienne P , et al. (1982). Reduced cortical choline acetyltransferase activity in Gertsmann–Sträussler syndrome. Prog NeuroPsychopharmacology, 6, 529–31.

Reference Title: References and further reading

Reference Type: reference-list

Brucki SMD , Nitrini R , Caramelli P , Bertolucci PHF , Okamoto IH (2003). [Suggestions for utilization of the Mini-mental state examination in Brazil]. Arq Neuropsiquiatr, 61, 777–81.
Folstein MF , Folstein SE , McHugh PR (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr Res, 12, 189–98.
Grant DA , Berg E (1980). The Wisconsin Card Sort Test Random Layout: Directions for Administration and Scoring. Madison, Wisconsin: Wells Printing.
Harwood DG , Sultzer DL , Feil D , Monserratt L , Freedman E , Mandelkern MA (2005). Frontal lobe hypometabolism and impaired insight in Alzheimer disease. Am J Geriatr Psychiatry, 13, 934–41.
Hooper H (1983). The Hooper Visual Organization Test (VOT) Manual. Los Angeles: Western Psychological Services.
Kaplan E , Goodglass H , Weintraub S (1983). The Boston Naming Test. Philadelphia: Lea and Febiger.
Knopman DS , DeKosky ST , Cummings JL , et al. (2001). Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56, 1143–53.
Lee JW , Wilck M , Venna N (2005). Dementia due to neurosyphilis with persistent negative CSF VDRL. Neurology, 65, 1838.
Malloy-Diniz LF , Lasmar VAP , Gazinelli LZR , Fuentes D , Salgado JV (2007). The Rey Auditory–Verbal Learning Test: applicability for the Brazilian elderly population. Rev Bras Psiquiatr, 29, 324–9.
Marra CM (2009). Update on neurosyphilis. Curr Infect Dis Rep, 11, 127–34.
Mattis S (1988). Dementia Rating Scale Professional Manual. Florida: Psychological Assessment Resources.
Merritt HH , Adams RD , Solomon HC (1946). Neurosyphilis. New York: Oxford University Press.
Neary D , Snowden JS , Gustafson L. et al. (1998). Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology, 51, 1546–54.
Nitrini R , Caramelli P , Bottino CM , Damasceno BP , Brucki SM , Anghinah R (2005). [Diagnosis of Alzheimer's disease in Brazil: diagnostic criteria and auxiliary tests. Recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology]. Arq Neuropsiquiatr, 63, 713–19.
Nitrini R , Caramelli P , Herrera E Jr, et al. (2004). Performance of illiterate and literate nondemented elderly subjects in two tests of long-term memory. J Int Neuropsychol Soc, 10, 634–8.
Nitrini R , Lefèvre BH , Mathias SC , et al. (1994). [Neuropsychological tests of simple application for diagnosing dementia]. Arq Neuropsiquiatr, 52, 457–65.
Nitrini R , Spina-França A (1987). [Intravenous penicillin therapy in high doses in neurosyphilis: study of 62 cases. II. Evaluation of cerebrospinal fluid]. Arq Neuropsiquiatr, 45, 231–41.
Nitrini R (2008). Clinical and therapeutic aspects of dementia in syphilis and Lyme disease. In C Duyckaerts , I Litvan (eds.), Dementias. Handbook of Clinical Neurology. Edinburgh; Elsevier, vol. 89, pp. 819–23.
Pfeffer RI , Kusosaki TT , Harrah CH Jr , Chance JM , Filos S (1982). Measurement of functional activities in older adults in the community. J Gerontol, 37, 323–9.
Porto, CS , Charchat-Fichman, H , Caramelli, P , Bahia, VS , Nitrini, R (2003). Brazilian version of the Mattis Dementia Rating Scale: diagnosis of mild dementia in Alzheimer's disease. Arq Neuropsiquiatr, 61, 339–45.
Reitan RM (1959). Correlations between the trail-making test and the Wechsler–Bellevue scale. Percept Motor Skills, 9, 127–30.
Rey A (1970). L'examen clinique en psychologie. Paris: Presses Universitaires de France.
Storm-Mathisen A (1978). Syphilis. In PJ Vinken , GW Bruyn (eds.), Infections of the Nervous System, part I. Handbook of Clinical Neurology. Amsterdam: Elsevier, vol. 33, pp. 337–94.
Sunderland T , Hill JL , Mellow AM , et al. (1989). Clock drawing in Alzheimer's disease: a novel measure of dementia severity. J Am Geriatr Soc, 37, 725–9.
Takada LT , Caramelli P , Radanovic M , et al. (2003). Prevalence of potentially reversible dementias in a dementia outpatient clinic of a tertiary university-affiliated hospital in Brazil. Arq Neuropsiquiatr, 61, 925–9.
Timermans M , Carr J (2004). Neurosyphilis in the modern era. J Neurol Neurosurg Psychiatry, 75, 1727–30.
Viskontas IK , Miller BL (2009). Frontotemporal dementia. In B.L.B.F. Boeve (eds.), The Behavioral Neurology of Dementia. Cambridge: Cambridge University Press.
Wechsler D (1987). Manual for the Wechsler Memory-revised. San Antonio, Texas: The Psychological Corporation.
Workowski KA , Berman SM (2006). Sexually transmitted diseases treatment guidelines 2006. MMWR Recomm Rep, 55, 1–94.

Reference Title: References and further reading

Reference Type: reference-list

Cranmer JM , Goldberg J (1986). Proceedings of the Workshop on Neurobehavioral Effects of Solvents. October 13–16, 1985, Raleigh, North Carolina, USA. Human aspects of solvent neurobehavioral effects. Neurotoxicology, 7(4), 1–123.
Kertesz A , Davidson W , Fox H (1997). Frontal behavioral inventory: diagnostic criteria for frontal lobe dementia. Can J Neurol Sci, 24(1), 29–36.
Kesic S , Calkoen F , Wenker MA , Jacobs JJ , Verberk MM (2006). Genetic polymorphism of metabolic enzymes modifies the risk of chronic solvent-induced encephalopathy. Toxicol Ind Health, 22, 281–9.
Knopman DS , deKosky S , Cummings J , et al. (2001). Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56(9), 1143–53.
Ridha B , Josephs KA (2006). Young-onset dementia: a practical approach to diagnosis. The Neurologist, 12, 2–13.
Sampson EL , Warren JD , Rossor MN (2004). Young onset dementia. Postgrad Med J, 80, 125–39.
White RF , Proctor SP (1997). Solvents and neurotoxicity. Lancet, 349, 1239–43.
WHO (World Health Organization)–Nordic Council of Ministers (1985). Organic Solvents and the Central Nervous System: chronic effects of organic solvents on the central nervous system and diagnostic criteria. EHS Copenhagen Denmark WHO–Nordic Council of Ministers 1985;1–39 WHO, Copenhagen.

Reference Title: References and further reading

Reference Type: reference-list

Berkhoff M , Weis J , Schroth G , Sturzenegger M (2001). Extensive white-matter changes in case of adult polyglucosan body disease. Neuroradiology, 3, 234–6.
Bigio EH , Weiner MF , Bonte FJ , White CL (1997). Familial dementia due to adult polyglucosan body disease. Clin Neuropathol, 4, 227–34.
Cavanagh JB (1999). Corpora-amylacea and the family of polyglucosan diseases. Brain Res Rev, 2 –3, 265–95.
Gray F , Gherardi R , Marshall A , Janota I , Poirier J (1988). Adult polyglucosan body disease (APBD). J Neuropathol Exp Neurol, 4, 459–74.
Klein CJ , Boes CJ , Chapin JE , et al. (2004). Adult polyglucosan body disease: case description of an expanding genetic and clinical syndrome. Muscle Nerve, 2, 323–8.
Lossos A , Meiner Z , Barash V , et al. (1998). Adult polyglucosan body disease in Ashkenazi Jewish patients carrying the Tyr329Ser mutation in the glycogen-branching enzyme gene. Ann Neurol, 6, 867–72.
Milde P , Guccion JG , Kelly J , Locatelli E , Jones RV (2001). Adult polyglucosan body disease. Arch Pathol Lab Med, 4, 519–22.
Peress NS , Dimauro S , Roxburgh VA (1979). Adult polysaccharidosis. Clinicopathological, ultrastructural, and biochemical features. Arch Neurol, 13, 840–5.
Rifai Z , Klitzke M , Tawil R , et al. (1994). Dementia of adult polyglucosan body disease. Evidence of cortical and subcortical dysfunction. Arch Neurol, 1, 90–4.
Savage G , Ray F , Halmagyi M , Blazely A , Harper C (2007). Stable neuropsychological deficits in adult polyglucosan body disease. J Clin Neurosci, 5, 473–7.
van der Knaap MS , Valk J (2005). Magnetic Resonance of Myelination and Myelin Disorders. New York: Springer.

Reference Title: References and further reading

Reference Type: reference-list

Bamford KA , Caine ED , Kido DK , et al. (1995). A prospective evaluation of cognitive decline in early Huntington's disease: Functional and radiographic correlates. Neurology, 45, 1867–73.
Beglinger LJ , Adams WH , Paulson H , et al. (2009). Randomized controlled trial of atomoxetine for cognitive dysfunction in early Huntington disease. J Clin Psychopharmacol, 29, 484–7.
Cubo E , Shannon KM , Tracy D , et al. (2006). Effect of donepezil on motor and cognitive function in Huntington disease. Neurology, 67, 1268–71.
Hamilton JM , Salmon DP , Corey-Bloom J , et al. (2003). Behavioural abnormalities contribute to functional decline in Huntington's disease. J Neurol Neurosurg Psychiatry, 74, 120–2.
Huntington Study Group (2006). Tetrabenazine as antichorea therapy in Huntington disease: A randomized controlled trial. Neurology, 66, 366–72.
Lemiere J , Decruyenaere M , Evers-Kiebooms G , et al. (2004). Cognitive changes in patients with Huntington's disease (HD) and asymptomatic carriers of the HD mutation: a longitudinal follow-up study. J Neurol, 251, 935–42.
Ondo WG , Mejia NI , Hunter CB (2007). A pilot study of the clinical efficacy and safety of memantine for Huntington's disease. Parkinsonism Relat Disord, 13, 453–4.
Paulsen JS , Langbehn DR , Stout JC , et al. (2008). Detection of Huntington's disease decades before diagnosis: the Predict-HD study. J Neurol Neurosurg Psychiatry, 79, 874–80.
Tabrizi SJ , Langbehn DR , Leavitt BR , et al. (2009). Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurology, 8, 791–801.
Zakzanis K (1998). The subcortical dementia of Huntington's disease. J Clin Exp Neuropsychol, 20, 565–78.

Reference Title: References and further reading

Reference Type: reference-list

Appleby BS , Appleby KK , Crain BJ , et al. (2009). Characteristics of established and proposed sporadic Creutzfeldt–Jakob disease variants. Arch Neurol, 66, 208–15.
Battaglia-Mayer A , Caminiti R (2002). Optic ataxia as a result of the breakdown of the global tuning fields of parietal neurones. Brain, 125, 225–37.
Giovagnoli AR , Di Fede G , Aresi A , et al. (2008). Atypical frontotemporal dementia as a new clinical phenotype of Gerstmann-Straussler-Scheinker disease with the PrP-P102L mutation. Description of a previously unreported Italian family. Neurol Sci, 29, 405–10.
Hamaguchi T , Noguchi-Shinohara M , Nozaki I , et al. (2009). The risk of iatrogenic Creutzfeldt–Jakob disease through medical and surgical procedures. Neuropathology 29, 625–31.
Kropp S , Schulz-Schaeffer WJ , Finkenstaet M , et al. (1999). The Heidenhain variant of Creutzfeldt–Jakob disease. Arch Neurol, 56, 55–61.
Li L , Napper S , Cashman N (2010). Immunotherapy for prion diseases: opportunities and obstacles. Immunotherapy, 2, 137–40.
Manuelidis EE , Manuelidis L (1989). Suspected links between different types of dementias: Creutzfeldt–Jakob disease, Alzheimer disease, and retroviral CNS infections. Alzheimer Dis Assoc Disord, 3, 100–9.
Novakovic KE , Villemagne VL , Rowe CC , et al. (2005). Rare genetically defined causes of dementia. Int Psychogeriat, 17, S149–94.
Parchi, P. , Giese, A. , Capellari, S. , et al. (1999). Classification of sporadic Creutzfeldt–Jakob disease based on molecular and phenotypic analysis of 300 subjects. Ann Neurol, 46, 224–33.
Peden AH , Head MW , Ritchie , et al. (2004). Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet, 264, 527–9.
Poser S , Mollenhauer B , Krauss A , et al. (1999). How to improve the clinical diagnosis of Creutzfeldt–Jakob disease. Brain, 12, 2345–51.
Spencer MD , Knight RSG , Will RG (2002). First hundred cases of variant Creutzfeldt–Jakob disease: retrospective case note review of early psychiatric and neurological features. BMJ, 324, 1479–82.
Stewart LA , Rydzewska LHM , Keogh GF , et al. (2008). Systematic review of therapeutic interventions in human prion disease. Neurology, 70, 1272–81.
Wieser HG , Schwarz U , Blaettler T , et al. (2004). Serial EEG findings in sporadic and iatrogenic Creutzfeldt–Jakob disease. Clin Neurophysiol, 115, 2467–78.

Reference Title: References and further reading

Reference Type: reference-list

Aarsland D , Litvan I , Salmon D , et al. (2003). Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease. J Neurol Neurosurg Psychiatry, 74, 1215–20.
Albert ML , Feldman RG , Willis AL (1974). The “subcortical dementia” of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry, 37, 121–30.
Bak TH , Rogers TT , Crawford LM , et al. (2005). Cognitive bedside assessment in atypical parkinsonian syndromes. J Neurol Neurosurg Psychiatry, 76, 420–2.
Borroni B , Malinverno M , Gardoni F , et al. (2008). Tau forms in CSF as a reliable biomarker for progressive supranuclear palsy. Neurology, 71, 1796–803.
Caparros-Lefebvre D , Steele J , Kotake Y , et al. (2006). Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: possible synergy of neurotoxins. Mov Disord, 21, 1769–71.
Delis DC , Kramer JH , Kaplan E , et al. (1987). California Verbal Learning Test: Research Edition. New York, NY: Psychological Corporation.
Dickson DW , Rademakers R , Hutton ML (2007). Progressive supranuclear palsy: pathology and genetics. Brain Pathol, 17, 74–82.
Dubois B , Deweer B Pillon B (1996). The cognitive syndrome of progressive palsy. Adv Neurol, 69, 399–403.
Dubois B , Slachevsky A , Litvan I , et al. (2000). The FAB: a frontal assessment battery at bedside. Neurology, 55, 1621–6.
Dubois B , Slachevsky A , Pillon B , et al. (2005). “Applause sign” helps to discriminate PSP from FTD and PD. Neurology, 64, 2132–3.
Folstein MF , Folstein SE , McHugh PR (1975). “Mini-mental state.” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res, 12, 189–98.
Imai H , Narabayashi H , Sakata E (1987). Pure akinesia and the later added supranuclear ophthalmoplegia. Adv Neurol, 45, 207–12.
Kaat LD , Boon AJ , Kamphorst W , et al. (2007). Frontal presentation in progressive supranuclear palsy. Neurology, 69, 723–9.
Lange KW , Tucha O , Alders GL , et al. (2003). Differentiation of parkinsonian syndromes according to differences in executive functions. J Neural Transm, 110, 983–95.
Litvan I (1994). Cognitive disturbances in progressive supranuclear palsy. J Neural Transm, 42, 69–78.
Litvan I , Agid Y , Calne D , et al. (1996). Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology, 47, 1–9.
Litvan I , Phipps M , Pharr VL , et al. (2001). Randomized placebo-controlled trial of donepezil in patients with progressive supranuclear palsy. Neurology, 57, 467–73.
Millar D , Griffiths P , Zermansky AJ (2006). Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy. Mov Disord, 21, 199–207.
Nasreddine ZS , Phillips NA , Bedirian V , et al. (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc, 53, 695–9.
Nath U , Ben-Shlomo Y , Thompson RG , et al. (2001). The prevalence of progressive supranuclear palsy (Steele–Richardson–Olszewski syndrome) in the UK. Brain, 124, 1438–49.
O'Sullivan SS , Massey LA , Williams DR , et al. (2008). Clinical outcomes of progressive supranuclear palsy and multiple system atrophy. Brain, 131, 1362–72.
Paviour DC , Price SL , Jahanshahi M , et al. (2006). Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy. Brain, 129,1040–9.
Rademakers R , Melquist S , Cruts M , et al. (2005). High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy. Hum Mol Genet, 14, 3281–92.
Rosser A , Hodges J (1994). The dementia rating scale in Alzheimer's disease, Huntington's disease and progressive supranuclear palsy. J Neurol, 241:531–6.
Sitburana O , Ondo WG (2009). Brain magnetic resonance imaging (MRI) in parkinsonian disorders. Parkinsonism Relat Disord, 15, 165–74.
Steele JC , Richardson JC , Olszewski J (1964). Progressive supranuclear palsy. Arch Neurol, 10, 333–59.
Williams DR , de Silva R , Paviour DC , et al. (2005). Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism. Brain, 128, 1247–58.
Williams DR , Holton JL , Strand C , et al. (2007). Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain, 130, 1566–76.
Williams DR , Lees AJ (2009). Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol, 8, 270–9.

Reference Title: References and further reading

Reference Type: reference-list

Clark DG , Charuvastra A , Miller BL , Shapira JS , Mendez MF (2005). Fluent versus nonfluent primary progressive aphasia: a comparison of clinical and functional neuroimaging features. Brain Language, 94, 54–60.
Deramecourt V , Lebert F , Debachy B , et al. (2010). Prediction of pathology in primary progressive language and speech disorders. Neurology, 74, 42–9.
Gorno-Tempini ML , Dronkers NF , Rankin KP , et al. (2004). Cognition and anatomy of three variants of primary progressive aphasia. Ann Neurol, 55, 335–46.
Karnik NS , D'Apuzzo M , Greicius M (2006). Non-fluent progressive aphasia, depression, and OCD in a woman with progressive supranuclear palsy: neuroanatomical and neuropathological correlations. Neurocase, 12, 332–8.
Knibb JA , Xuereb JH , Patterson K , Hodges JR (2006). Clinical and pathological characterization of progressive aphasia. Ann Neurol, 59, 156–65.
Litvan I , Agid Y , Calne D , et al. (1996). Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology, 47, 1–9.
Mesulam MM (1982). Slowly progressive aphasia without generalized dementia. Ann Neurol, 11, 592–8.
Mesulam MM (2003). Primary progressive aphasia – a language-based dementia. N Engl J Med, 349, 1535–42.
Mochizuki A , Ueda Y , Komatsuzaki Y , Tsuchiya K , Arai T , Shoji S (2003). Progressive supranuclear palsy presenting with primary progressive aphasia – clinicopathological report of an autopsy case. Acta Neuropathol, 105, 610–14.
Rogalski E , Mesulam M (2007). An update on primary progressive aphasia. Curr Neurol Neurosci Rep, 7, 388–92.
Senaha MLH , Caramelli P , Porto CS , Nitrini R (2007). Semantic dementia: Brazilian study of 19 cases. Dementia Neuropsych, 1, 366–73.
Westburry C , Bub D (1997). Primary progressive aphasia: a review of 112 cases. Brain Language, 60, 381–406.

Reference Title: References and further reading

Reference Type: reference-list

Bech-Azeddine R , Høgh P , Juhler M , Gjerris F , Waldemar G (2007). Idiopathic normal pressure hydrocephalus: clinical comorbidity correlated to cerebral biopsy findings and outcome of CSF shunting. J Neurol Neurosurg Psychiatry, 78(2), 157–61.
Boon AJ , Tans JT , Delwel EJ , et al. (1997). Dutch normal-pressure hydrocephalus study: prediction of outcome after shunting by resistance to outflow of cerebrospinal fluid. J Neurosurg, 87(5), 687–93.
Curran T , Lang AE (1994). Parkinsonian syndromes associated with hydrocephalus: case reports, a review of the literature, and pathophysiological hypotheses. Mov Disord, 9, 508–20.
Golomb J , Wisoff J , Miller DC , et al. (2000). Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response. J Neurol Neurosurg Psychiatry, 68, 778–81.
Krauss JK , Regel JP , Vach W , Droste DW , Borremans JJ , Mergner T (1996). Vascular risk factors and arteriosclerotic disease in idiopathic normal-pressure hydrocephalus of the elderly. Stroke, 27, 24–9.
Mandir AS , Hilfiker J , Thomas G , et al. (2007). Extrapyramidal signs in normal pressure hydrocephalus: an objective assessment. Cerebrospinal Fluid Res, 13, 4–7.
Marmarou A , Bergsneider M , Relkin N , Klinge P , Black PM (2005). Development of guidelines for idiopathic normal-pressure hydrocephalus: introduction. Neurosurgery, 57(3 Suppl), S40–52.
Silverberg GD , Mayo M , Saul T , Rubenstein E , McGuire D (2003). Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis. Lancet Neurol, 2, 506–11.
Snijders AH , van de Warrenburg BP , Giladi N , Bloem BR (2007). Neurological gait disorders in elderly people: clinical approach and classification. Lancet Neurol, 6(1), 63–74.
Sudarsky L (1997). Clinical Approach to Gait Disorders of Aging: an Overview. Philadelphia: Lippincott-Raven.
Sudarsky L (2001). Gait disorders prevalence, morbidity, and etiology. Adv Neurol, 87, 111–17.
Verghese J , Cuiling W , Lipton RB , Holtzer R , Xiaonan X (2007). Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry, 78, 929–35.

Reference Title: References and further reading

Reference Type: reference-list

Burn DJ , Lees AJ (2002). Progressive supranuclear palsy: Where are we now? Lancet Neurology, 1, 359–69.
Constantinescu, R , Rosengren L , Johnels B , Zetterberg H , Holberg B (2010). Consecutive analyses of cerebrospinal fluid axonal and glial markers in Parkinson's disease and atypical Parkinsonian disorders. Parkinsonism Rel Disord, 16, 142–5.
Dickson DW , Rademakers R , Hutton ML (2007). Progressive supranuclear palsy: pathology and genetics. Brain Pathol, 17, 74–82.
Golbe LI (2001). Progressive supranuclear palsy. Curr Treat Options Neurol, 3, 473–7.
Golbe LI , Ohman-Strickland PA (2007). A clinical rating scale for progressive supranuclear palsy. Brain, 130, 1552–65.
Litvan I , Agid Y , Calne D , et al. (1996). Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele Richardson–Olszewski syndrome): report of the NINDS-SPSP International Workshop. Neurology, 47, 1–9.
Schrag A , Good CD , Miszkiel K , et al. (2000). Differentiation of atypical parkinsonian syndromes with routine MRI. Neurology, 54, 697–702.
Williams DR , Holton JL , Strand K , Revesz T , Lees AJ (2007). Pure akinesia with gait freezing: a third clinical phenotype of progressive supranuclear palsy. Mov Disord, 22, 2235–41.
Williams DR , Lees AJ (2010). What features improve the accuracy of the clinical diagnosis of progressive supranuclear palsy–parkinsonism (PSP–P)? Mov Disord 00, 000–000.

Reference Title: References and further reading

Reference Type: reference-list

Berg EA (1948). A simple objective treatment for measuring flexibility in thinking. J Gen Psychol, 39, 15–22.
Charness ME , Simon RP , Greenberg DA (1989). Ethanol and the nervous system. N Engl J Med, 321 (7), 442–53.
Doody RS , Strehlow SL , Massman PJ , Feher EP , Clark C , Roy JR (1999). Baylor Profound Mental Status Examination: a brief staging measure for profoundly demented Alzheimer disease patients. Alz Dis Assoc Dis, 13(1), 53–9.
Folstein MF , Folstein SE , McHugh PR (1975). “Mini Mental State”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res, 12(3), 189–98.
Mahurin R , Cooke N (1996). The Verbal Series Attention Test: Clinical utility in the assessment of dementia. Clin Neuropsychol, 1043–52.
Osterrieth PA (1944). Le test de copie d'une figure complexe. Archives de Psychologie, 30, 206–356; translated by J. Corwin and F.W. Bylsma (1993), The Clinical Neuropsychologist, 7, 9–15.
Sechi GP , Serra A (2007). Wenicke's encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol, 6, 442–55.
Wechsler D (1997). Wechsler Memory Scale-Revised. San Antonio: Psychological Corporation.

Reference Title: References and further reading

Reference Type: reference-list

Black SE (2007). Therapeutic issues in vascular dementia: studies, designs, and approaches. Can J Neurol Sci, 34 (Suppl 1), S125–30.
Darvesh S , Leach L , Black SE , Kaplan E , Freedman M (2005). The behavioural neurology assessment. Can J Neurol Sci, 32, 167–77.
Eroglu Y , Bryne WJ (2009). Hepatic encephalopathy. Emerg Med Clin North Am, 27, 401–14.
Freedman M , Leach L , Kaplan E , et al. (1994). Clock Drawing: A Neuropsychological Analysis. New York: Oxford University Press.
Fridman V , Galetta SL , Pruitt AA , Levine JM (2009). MRI findings associated with acute liver failure. Neurology, 72, 2130–3.
Gillioz AS , Villars H , Voisin T , et al. (2009). Spared and impaired abilities in community-dwelling patterns entering the severe stage of Alzheimer's disease. Dement Geriatr Cogn Disord, 28(5), 427–32.
Hazell AS , Butterworth RF (1999). Hepatic encephalopathy: an update of pathophysiologic mechanisms. Proc Soc Exp Biol Med, 222(2), 99–112.
Miyata K , Tamai H , Uno A , et al. (2009). Congenital portal systemic encephalopathy misdiagnosed as senile dementia. Intern Med, 48(5), 321–4.
Rothenberg LS (1992). Withholding and withdrawing dialysis from elderly ESRD patients: part 1 – a historical view of the clinical experience. Geriatr Nephrol Urol, 2(2), 109–17.

Reference Title: References and further reading

Reference Type: reference-list

Amemiya S , Hamamoto M , Goto Y , et al. (2000). Psychosis and progressing dementia: presenting features of a mitochondriopathy. Neurology, 55, 600–1.
Finsterer J (2008). Cognitive decline as a manifestation of mitochondrial disorders (mitochondrial dementia). J Neurol Sci, 272, 20–33.
Goto Y , Nonaka I , Horai S (1990). A mutation in the tRNA (Leu) (UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature, 348, 651–3.
Iizuka T , Sakai F , Suzuki N , et al. (2002). Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome. Neurology, 59, 816–24.
Ikawa M , Okazawa H , Arakawa K , et al. (2009). PET imaging of redox and energy states in stroke-like episodes of MELAS. Mitochondrion, 9, 144–8.
Kaufmann P , Shungu DC , Sano MC , et al. (2004). Cerebral lactic acidosis correlates with neurological impairment in MELAS. Neurology, 62, 1297–302.
Koga Y , Akita Y , Nishioka J , et al. (2005). L-arginine improves the symptoms of stroke-like episodes in MELAS. Neurology, 64, 710–12.
Koga Y , Akita Y , Nishioka J , et al. (2006). Endothelial dysfunction in MELAS was improved by L-arginine supplementation. Neurology, 66, 1766–9.
Koller H , Kornischka J , Neuen-Jacob E , et al. (2003). Persistent organic personality change as rare psychiatric manifestation of MELAS syndrome. J Neurol, 250, 1501–2.
Kuriyama M , Umezaki H , Fukuda Y , et al. (1984). Mitochondrial encephalomyopathy with lactate-pyruvate elevation and brain infarctions. Neurology, 34, 72–7.
Moller HE , Kurlemann G , Putzler M , et al. (2005). Magnetic resonance spectroscopy in patients with MELAS. J Neurol Sci, 229–230, 131–9.
Ohama E , Ohara S , Ikuta F , et al. (1987). Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy. Acta Neuropathol, 74, 226–33.
Pavlakis SG , Phillips PC , DiMauro S , et al. (1984). Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol, 16, 481–8.
Tsujikawa T , Yoneda M , Shimizu Y , et al. (2010). Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images. Brain Dev, 32, 143–9.
Yoneda M , Maeda M , Kimura H , et al. (1999). Vasogenic edema on MELAS: a serial study with diffusion-weighted MR imaging. Neurology, 53, 2182–4.

Reference Title: Further reading

Reference Type: further-reading

Arata J , Takashima H , Hirano R , et al. (2006). Early clinical signs and imaging findings in Gerstmann–Sträussler–Scheinker syndrome (Pro102Leu). Neurology, 66, 1672–8.
Hsiao K , Baker HF , Crow TJ , et al. (1989). Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome. Nature 338, 342–5.
Ironside JW , Head MW (2004). Neuropathology and molecular biology of variant Creutzfeldt–Jakob disease. Curr Top Microbiol Immunol, 284, 133–59.
Kovacs GG , Puopolo M , Ladogana A , et al. (2005). Genetic prion disease: the EUROCJD experience. Hum Genet, 118, 166–74.
Rossor MN , Fox NC , Mummery CJ , Schott JM , Warren JD (2010). The diagnosis of young-onset dementia. Lancet Neurol, 9(8), 793–806.
Wadsworth JD , Collinge J (2010). Molecular pathology of human prion disease. Acta Neuropathol, in press.

Reference Title: References and suggested reading

Reference Type: reference-list

Ali ZS , Van Der Voorn JP , Powers JM (2007). A comparative morphologic analysis of adult onset leukodystrophy with neuroaxonal spheroids and pigmented glia–a role for oxidative damage. Journal of Neuropathology and Experimental Neurology, 66(7), 660–72. doi:10.1097/nen.0b013e3180986247
Baba Y , Ghetti B , Baker MC , Uitti RJ , Hutton ML , Yamaguchi K , Bird T , Lin W , DeLucia MW , Dickson DW , Wszolek ZK (2006). Hereditary diffuse leukoencephalopathy with spheroids: Clinical, pathologic and genetic studies of a new kindred. Acta Neuropathologica, 111(4), 300–11. doi:10.1007/s00401-006-0046-z
Chui HC , Victoroff JI , Margolin D , Jagust W , Shankle R , Katzman R (1992). Criteria for the diagnosis of ischemic vascular dementia proposed by the state of california alzheimer's disease diagnostic and treatment centers. Neurology, 42(3 Pt 1), 473–80.
Costello DJ , Eichler AF , Eichler FS (2009). Leukodystrophies: Classification, diagnosis, and treatment. The Neurologist, 15(6), 319–28. doi:10.1097/NRL.0b013e3181b287c8
Doody RS , Pavlik V , Massman P , Rountree S , Darby E , Chan W (2010). Predicting progression of alzheimer's disease. Alzheimer's Research & Therapy, 2(1), 2. doi:10.1186/alzrt25
Freeman SH , Hyman BT , Sims KB , Hedley-Whyte ET , Vossough A , Frosch MP , Schmahmann JD (2009). Adult onset leukodystrophy with neuroaxonal spheroids: Clinical, neuroimaging and neuropathologic observations. Brain Pathology (Zurich, Switzerland), 19(1), 39–47. doi:10.1111/j.1750-3639.2008.00163.x
Lopez OL , Wisniewski S , Hamilton RL , Becker JT , Kaufer DI , DeKosky ST (2000). Predictors of progression in patients with AD and lewy bodies. Neurology, 54(9), 1774–9.
O'Sullivan M , Jarosz JM , Martin RJ , Deasy N , Powell JF , Markus HS (2001). MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. Neurology, 56(5), 628–34.
Petersen RC , Morris JC (2005). Mild cognitive impairment as a clinical entity and treatment target. Archives of Neurology, 62(7), 1160–3; discussion 1167. doi:10.1001/archneur.62.7.1160
Portet F , Scarmeas N , Cosentino S , Helzner EP , Stern Y (2009). Extrapyramidal signs before and after diagnosis of incident alzheimer disease in a prospective population study. Archives of Neurology, 66(9), 1120–6. doi:10.1001/archneurol.2009.196
Ridha B , Josephs KA (2006). Young-onset dementia: A practical approach to diagnosis. The Neurologist, 12(1), 2–13. doi:10.1097/01.nrl.0000186798.86255.069
Rudzinski LA , Fletcher RM , Dickson DW , Crook R , Hutton ML , Adamson J , Graff-Radford NR (2008). Early onset familial alzheimer disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1. Alzheimer Disease and Associated Disorders, 22(3), 299–307. doi:10.1097/WAD.0b013e3181732399
Sampson EL , Warren JD , Rossor MN (2004). Young onset dementia. Postgraduate Medical Journal, 80(941), 125–39.
Scarmeas N , Honig LS , Choi H , Cantero J , Brandt J , Blacker D , Albert M , Amatniek JC , Marder K , Bell K , Hauser WA , Stern Y (2009). Seizures in alzheimer disease: Who, when, and how common? Archives of Neurology, 66(8), 992–7. doi:10.1001/archneurol.2009.130
Schott JM , Fox NC , Rossor MN (2002). Genetics of the dementias. Journal of Neurology, Neurosurgery, and Psychiatry, 73 Suppl 2, II27–31.
Staekenborg SS , van der Flier WM , van Straaten EC , Lane R , Barkhof F , Scheltens P (2008). Neurological signs in relation to type of cerebrovascular disease in vascular dementia. Stroke; a Journal of Cerebral Circulation, 39(2), 317–22. doi:10.1161/STROKEAHA.107.493353
Tournier-Lasserve E , Iba-Zizen MT , Romero N , Bousser MG (1991). Autosomal dominant syndrome with strokelike episodes and leukoencephalopathy. Stroke; a Journal of Cerebral Circulation, 22(10), 1297–302.
Whiteman ML , Post MJ , Berger JR , Tate LG , Bell MD , Limonte LP (1993). Progressive multifocal leukoencephalopathy in 47 HIV-seropositive patients: Neuroimaging with clinical and pathologic correlation. Radiology, 187(1), 233–40.
Wider C , Van Gerpen JA , DeArmond S , Shuster EA , Dickson DW , Wszolek ZK (2009). Leukoencephalopathy with spheroids (HDLS) and pigmentary leukodystrophy (POLD): A single entity? Neurology, 72(22), 1953–59. doi:10.1212/WNL.0b013e3181a826c0