Chapter 26 - Pediatric liver transplantation  pp. 220-230

Pediatric liver transplantation

By Hector Vilca-Melendez and Giorgina Mieli-Vergani

Image View Previous Chapter Next Chapter



As more and more children have undergone liver transplantation (LT), the shortage of size-matched donors has become more of a concern and has led to the development of new surgical techniques based on the segmental anatomy of the liver. The use of reduced liver, as originally described by Bismuth and colleagues, provides a suitable size graft for a child, but wastes the rest of the liver mass. The so called “split” LT then evolved to provide two viable partial grafts that could be shared between a child and an adult. Living related LT has also played an important role in reducing the waiting time for a cadaveric organ and has now become a routine procedure in pediatric LT (discussed further in Chapter 22).

Bartlett ARela MProgress in surgical techniques in pediatric liver transplantationPediatr Transplant20101433
Bucuvalas JLong-term outcomes in pediatric liver transplantationLiver Transpl200915S6
Dhawan AEtiology and prognosis of acute liver failure in childrenLiver Transpl200814S80
Duffy JKao KKo CLong-term patient outcome and quality of life after liver transplantation: analysis of 20-year survivorsAnn Surg2010252652
Hartley JDavenport MKelly DBiliary atresiaLancet20093741704
Mieli-Vergani GVergani DAutoimmune paediatric liver diseaseWorld J Gastroenterol2008143360
Muiesan PVergani DMieli-Vergani GLiver transplantation in childrenJ Hepatol200746340