50 - Injectable ibuprofen  pp. 218-221

Injectable ibuprofen

By James H. Shull

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Generic Name: injectable ibuprofen

Trade Name: Caldolor™

Chemical Class: nonsteroidal anti-inflammatory drug

Manufacturer: Cumberland Pharmaceuticals, Nashville, TN

Chemical Name: D2-(4-isobutylphenyl)propanoic acid

Chemical Structure: see Figure 50.1


Ibuprofen is a nonsteroidal anti-inflammatory drug with a long history that has found a broad range of uses in a wide variety of clinical settings. Initially released in oral form in the UK in 1969 (and later in the USA in 1974) as a treatment for rheumatoid arthritis, ibuprofen is now used to treat acute and chronic pain, fever, inflammation and as an anti-platelet agent. Although originally released as an oral agent, later an injectable form became available in Europe, Australia, and New Zealand and has been used as an alternative to indomethacin in the treatment of patent ductus arteriosus. Injectable ibuprofen was recently studied, FDA-approved and introduced to the US market by Cumberland Pharmaceuticals under the trade name Caldolor®. Injectable ibuprofen in the USA is marketed both as an analgesic for use in mild to moderate pain and as an adjunct to opiods in the treatment of moderate to severe pain. In addition to its use as an analgesic, injectable ibuprofen may also be useful as an antipyretic in patients, for whom oral ibuprofen is not an option, although it is not FDA-approved for this indication.

Caldolor® product monograph: available from Cumberland Pharmaceuticals, Nashville, TN.
Data on file Cumberland Pharmaceuticals Inc.
Kroll P , Meadows L , Rock A , et al. Randomized double blind, placebo-controlled trial of ibuprofen injection for treatment of pain in postoperative adult patients. Poster #50, 20th Annual AAPM Meeting, October 10, 2009
Southworth S , Peters J , Ludbrook G , et al. A multicenter, randomized, double- blind, placebo-controlled trial of intravenous ibuprofen for the management of postoperative pain in adults. Clin Ther 2009;31:1–13.
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