26 - Methadone  pp. 127-131

Methadone

By Keun Sam Chung
Eap CB , Buclin T , Baumann P . Interindividual variability of the clinical pharmacokinetics of methadone; implications for the treatment of opioid dependence. Clin Pharmacokinet 2002;41(14):1153–1193.
Fishman SM , Wilsey B , Mahajian G , Molina P . Methadone reincarnated: novel clinical applications with related concerns. Pain Med 2002;3:339–348.
Gourlay GK , Willis RJ , Wilson PR . Post-operative pain control with methadone: influence of supplementary doses and blood concentration – response relationships. Anesthesiology 1984;61:19–26.
Kharasch ED , Hoffer C , Whittington D , Walker A , Bedynek PS . Methadone pharmacokinetics are independent of Cytochrome P4503A (CYP3A) activity and gastrointestinal transport. Insights from methadone interactions with ritonavir/indinavir. Anesthesiology 2009;110:660–672.
Toombs JD , Kral LA . Methadone treatment for pain states. Am Fam Physician 2005;1(7):1353–1358.