22 - Neurobiological and neuropsychological pathways into substance abuse and addictive behavior  pp. 326-341

Neurobiological and neuropsychological pathways into substance abuse and addictive behavior

By Murat Yücel, Dan I. Lubman, Nadia Solowij and Warrick J. Brewer

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Introduction and overview

“Addiction,” derived from the Latin verb addicere (meaning “to enslave”), is characterized by the apparent “loss of control” or autonomy over one's behavior. Indeed, the continued use of substances by addicted individuals, despite an apparent awareness of the adverse negative consequences, suggests that addictive behavior may involve deficits in inhibitory control, decision-making and the regulation of affect (Bechara et al., 2001; Fillmore, 2003; Goldstein & Volkow, 2002; Grant et al., 2000; Jentsch & Taylor, 1999; Lubman et al., 2004; Yücel & Lubman, 2007). Recent neuropsychological and neuroimaging studies across a variety of substance-using populations support this notion, implicating impairments in frontal cortical systems critically involved in executive control (Everitt et al., 2001; Rogers & Robbins, 2001). However, an important question that remains is why only a minority of individuals who experiment with addictive substances develop problematic substance-use patterns. This chapter explores this issue from a neuropsychological perspective, specifically focusing on the neuropsychological aspects of addictive behavior (including neuroimaging findings where relevant) under three main sections:

  • (1) Neuropsychological sequelae of specific substances and their role in addictive behaviors. This section will briefly discuss the evidence for specific neuropsychological and neurobiological effects of several major classes of substances including alcohol, cannabis, inhalants, stimulants, opiates and ecstasy. The section ends with a summary of the major findings across the various substances, highlighting consistent evidence for problems in prefrontally mediated functions (such as inhibitory control, decision-making and affect regulation).
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Acton, G. S. (2003). Measurement of impulsivity in a hierarchical model of personality traits: implications for substance use. Substance Use and Misuse, 38, 67–83.
Ardila, A., Rosselli, M. & Strumwasser, S. (1991). Neuropsychological deficits in chronic cocaine abusers. International Journal of Neuroscience, 57, 73–79.
Bartzokis, G., Beckson, M., Lu, P. H. et al. (2000). Age-related brain volume reductions in amphetamine and cocaine addicts and normal controls: implications for addiction research. Psychiatry Research, 98, 93–102.
Beatty, W. W., Tivis, R., Stott, H. D., Nixon, S. J. & Parsons, O. A. (2000). Neuropsychological deficits in sober alcoholics: influences of chronicity and recent alcohol consumption. Alcoholism, Clinical and Experimental Research, 24, 149–54.
Bechara, A., Dolan, S., Denburg, N. et al. (2001). Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia, 39, 376–389.
Berry, G., Heaton, R. & Kirby, M. (1977). Neuropsychological deficits of chronic inhalant abusers. In B. Rumac. & A. Temple (Eds.), Management of the Poisoned Patient (pp. 9–31). Princeton, NJ: Science Press.
Beuten, J., Payne, T. J., Ma, J. Z. & Li, M. D. (2006). Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. Neuropsychopharmacology, 31, 675–684.
Block, R. I., O'Leary, D. S., Ehrhardt, J. C. et al. (2000). Effects of frequent marijuana use on brain tissue volume and composition. Neuroreport, 11, 491–496.
Bogenschutz, M. P. & Nurnberg, H. G. (2000). Theoretical and methodological issues in psychiatric comorbidity. Harvard and Review of Psychiatry, 8, 18–24.
Bolla, K. I., Brown, K., Eldreth, D., Tate, K. & Cadet, J. L. (2002). Dose-related neurocognitive effects of marijuana use. Neurology, 59, 1337–1343.
Bolla, K. I., Eldreth, D. A., Matochik, J. A. & Cadet, J. L. (2005). Neural substrates of faulty decision-making in abstinent marijuana users. Neuroimage, 26, 480–492.
Bolla, K. I., Mccann, U. D. & Ricaurte, G. A. (1998). Memory impairment in abstinent MDMA (“Ecstasy”) users. Neurology, 51, 1532–1537.
Bolla, K. I., Rothman, R. & Cadet, J. L. (1999). Dose-related neurobehavioral effects of chronic cocaine use. Journal of Neuropsychiatry and Clinical Neuroscience, 11, 361–369.
Bowden-Jones, H., McPhillips, M., Rogers, R., Hutton, S. & Joyce, E. (2005). Risk-taking on tests sensitive to ventromedial prefrontal cortex dysfunction predicts early relapse in alcohol dependency: a pilot study. Journal of Neuropsychiatry and Clinical Neuroscience, 17, 417–420.
Brady, K. T. & Sinha, R. (2005). Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress. American Journal of Psychiatry, 162, 1483–1493.
Brust, J. (1993). Neurological Aspects of Substance Abuse. Boston, MA: Butterworth-Heinemann.
Button, T. M., Hewitt, J. K., Rhee, S. H. et al. (2006). Examination of the causes of covariation between conduct disorder symptoms and vulnerability to drug dependence. Twin Research and Human Genetics, 9, 38–45.
Cairney, S., Maruff, P., Burns, C. & Currie, B. (2002). The neurobehavioural consequences of petrol (gasoline) sniffing. Neuroscience and Biobehavior Review, 26, 81–89.
Cairney, S., Maruff, P., Burns, C. B., Currie, J. & Currie, B. J. (2004a). Neurological and cognitive impairment associated with leaded gasoline encephalopathy. Drug and Alcohol Dependence, 73, 183–188.
Cairney, S., Maruff, P., Burns, C. B., Currie, J. & Currie, B. J. (2004b). Saccade dysfunction associated with chronic petrol sniffing and lead encephalopathy. Journal of Neurologyery Neurosurgery and Psychiatry, 75, 472–476.
Cairney, S., Maruff, P., Burns, C. B., Currie, J. & Currie, B. J. (2005). Neurological and cognitive recovery following abstinence from petrol sniffing. Neuropsychopharmacology, 30, 1019–1027.
Chadwick, O., Anderson, R., Bland, M. & Ramsey, J. (1989). Neuropsychological consequences of volatile substance abuse: a population based study of secondary school pupils. British Medical Journal, 298, 1679–1683.
Chassin, L., Fora, D. B. & King, K. M. (2004). Trajectories of alcohol and drug use and dependence from adolescence to adulthood: the effects of familial alcoholism and personality. Journal of Abnormal Psychology, 113, 483–498.
Chassin, L., Pillow, D. R., Curran, P. J., Molina, B. S. & Barrera, M., Jr. (1993). Relation of parental alcoholism to early adolescent substance use: a test of three mediating mechanisms. Journal of Abnormal Psychology, 102, 3–19.
Conway, K. P., Compton, W., Stinson, F. S. & Grant, B. F. (2006). Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Journal of Clinical Psychiatry, 67, 247–257.
Corral-Varela, M. & Cadaveira, F. (2002). Neuropsychological aspects of alcohol dependence: the nature of brain damage and its reversibility. Reviews in Neurology, 35, 682–687.
Cowan, R. L., Lyoo, I. K., Sung, S. M. et al. (2003). Reduced cortical gray matter density in human MDMA (Ecstasy) users: a voxel-based morphometry study. Drug and Alcohol Dependence, 72, 225–235.
Darke, S., Sims, J., McDonald, S. & Wickes, W. (2000). Cognitive impairment among methadone maintenance patients. Addiction, 95, 687–695.
Daumann, J., Fischermann, T., Heekeren, K. et al. (2005). Memory-related hippocampal dysfunction in poly-drug ecstasy (3,4-methylenedioxymethamphetamine) users. Psychopharmacology (Berlin), 180, 607–611.
Daumann, J., Jr., Fischermann, T., Heekeren, K., Thron, A. & Gouzoulis-Mayfrank, E. (2004). Neural mechanisms of working memory in ecstasy (MDMA) users who continue or discontinue ecstasy and amphetamine use: evidence from an 18-month longitudinal functional magnetic resonance imaging study. Biological Psychiatry, 56, 349–355.
Daumann, J., Pelz, S., Becker, S., Tuchtenhagen, F. & Gouzoulis-Mayfrank, E. (2001). Psychological profile of abstinent recreational ecstasy (MDMA) users and significance of concomitant cannabis use. Human Psychopharmacology, 16, 627–633.
Daumann, J., Schnitker, R., Weidemann, J. et al. (2003). Neural correlates of working memory in pure and polyvalent ecstasy (MDMA) users. Neuroreport, 14, 1983–1987.
Davis, P. E., Liddiard, H. & Mcmillan, T. M. (2002). Neuropsychological deficits and opiate abuse. Drug and Alcohol Dependence, 67, 105–108.
Dawe, S., Gullo, M. J. & Loxton, N. J. (2004). Reward drive and rash impulsiveness as dimensions of impulsivity: implications for substance misuse. Addictive Behavior, 29, 1389–1405.
De Bellis, M. D., Clark, D. B., Beers, S. R. et al. (2000). Hippocampal volume in adolescent-onset alcohol use disorders. American Journal of Psychiatry, 157, 737–744.
De Bellis, M. D., Narasimhan, A., Thatcher, D. L. et al. (2005). Prefrontal cortex, thalamus, and cerebellar volumes in adolescents and young adults with adolescent-onset alcohol use disorders and comorbid mental disorders. Alcoholism, Clinical and Experimental Research, 29, 1590–1600.
Di Sclafani, V., Tolou-Shams, M., Price, L. J. & Fein, G. (2002). Neuropsychological performance of individuals dependent on crack-cocaine, or crack-cocaine and alcohol, at 6 weeks and 6 months of abstinence. Drug and Alcohol Dependence, 66, 161–171.
Diamond, A., Briand, L., Fossella, J. & Gehlbach, L. (2004). Genetic and neurochemical modulation of prefrontal cognitive functions in children. American Journal of Psychiatry, 161, 125–132.
Eckardt, M. J., File, S. E., Gessa, G. L. et al. (1998). Effects of moderate alcohol consumption on the central nervous system. Alcoholism, Clinical and Experimental Research, 22, 998–1040.
Egan, M. F., Goldberg, T. E., Kolachana, B. S. et al. (2001). Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences USA, 98, 6917–6922.
Ehrenreich, H., Rinn, T., Kunert, H. J. et al. (1999). Specific attentional dysfunction in adults following early start of cannabis use. Psychopharmacology (Berlin), 142, 295–301.
Eldreth, D. A., Matochik, J. A., Cadet, J. L. & Bolla, K. I. (2004). Abnormal brain activity in prefrontal brain regions in abstinent marijuana users. Neuroimage, 23, 914–920.
Ernst, T., Chang, L., Leonido-Yee, M. & Speck, O. (2000). Evidence for long-term neurotoxicity associated with methamphetamine abuse: a 1H MRS study. Neurology, 54, 1344–1349.
Ersche, K. D., Clark, L., London, M., Robbins, T. W. & Sahakian, B. J. (2006). Profile of executive and memory function associated with amphetamine and opiate dependence. Neuropsychopharmacology, 31, 1036–1047.
Ersche, K. D., Fletcher, P. C., Lewis, S. J. et al. (2005). Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals. Psychopharmacology (Berlin), 180, 612–623.
Everitt, B. J., Dickinson, A. & Robbins, T. W. (2001). The neuropsychological basis of addictive behaviour. Brain Research Brain Research Reviews, 36, 129–138.
Fein, G., Di Sclafani, V. & Meyerhoff, D. J. (2002). Prefrontal cortical volume reduction associated with frontal cortex function deficit in 6-week abstinent crack-cocaine dependent men. Drug and Alcohol Dependence, 68, 87–93.
Fiedler, N., Weisel, C., Lynch, R. et al. (2003). Cognitive effects of chronic exposure to lead and solvents. American Journal of Industrial Medicine, 44, 413–423.
Fillmore, M. T. (2003). Drug abuse as a problem of impaired control: current approaches and findings. Behavioral and Cognitive Neuroscience Reviews, 2, 179–197.
Fishbein, D. H., Herman-Stahl, M., Eldreth, D. et al. (2006). Mediators of the stress-substance-use relationship in urban male adolescents. Prevention Science, 7, 113–126.
Fletcher, J. M., Page, J. B., Francis, D. J. et al. (1996). Cognitive correlates of long-term cannabis use in Costa Rican men. Archives of General Psychiatry, 53, 1051–1057.
Giedd, J. N., Blumenthal, J., Jeffries, N. O. et al. (1999). Brain development during childhood and adolescence: a longitudinal MRI study. Nature Neuroscience, 2, 861–863.
Gogtay, N., Giedd, J. N., Lusk, L. et al. (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences USA, 101, 8174–8179.
Goldstein, R. Z. & Volkow, N. D. (2002). Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry, 159, 1642–1652.
Gonzalez, R., Rippeth, J. D., Carey, C. L. et al. (2004). Neurocognitive performance of methamphetamine users discordant for history of marijuana exposure. Drug and Alcohol Dependence, 76, 181–190.
Goudriaan, A. E., Oosterlaan, J., De Beurs, E. & Van Den Brink, W. (2006). Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls. Addiction, 101, 534–547.
Gouzoulis-Mayfrank, E. & Daumann, J. (2006). Neurotoxicity of methylenedioxyamphetamines (MDMA; ecstasy) in humans: how strong is the evidence for persistent brain damage? Addiction, 101, 348–361.
Gouzoulis-Mayfrank, E., Schreckenberger, M., Sabri, O. et al. (1999). Neurometabolic effects of psilocybin, 3,4-methylenedioxyethylamphetamine (MDE) and d-methamphetamine in healthy volunteers. A double-blind, placebo-controlled PET study with [18F]FDG. Neuropsychopharmacology, 20, 565–581.
Grant, S., Contoreggi, C. & London, E. D. (2000). Drug abusers show impaired performance in a laboratory test of decision making. Neuropsychologia, 38, 1180–1187.
Gruber, S. A. & Yurgelun-Todd, D. A. (2005). Neuroimaging of marijuana smokers during inhibitory processing: a pilot investigation. Brain Research Cognitive Brain Research, 23, 107–118.
Guerra, D., Sole, A., Cami, J. & Tobena, A. (1987). Neuropsychological performance in opiate addicts after rapid detoxification. Drug and Alcohol Dependence, 20, 261–270.
Harrison, G. P., Jr., Gruber, A. J., Hudson, J. I., Huestis, M. A. & Yurgelun-Todd, D. (2002). Cognitive measures in long-term cannabis users. Journal of Clinical Pharmacology, 42, 41S–47S.
Hasin, D. S., Goodwin, R. D., Stinson, F. S. & Grant, B. F. (2005). Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Archives of General Psychiatry, 62, 1097–1106.
Hides, L., Lubman, D. I. & Dawe, S. (2004). Models of co-occurring substance misuse and psychosis: are personality traits the missing link? Drug and Alcohol Review, 23, 425–432.
Hommer, D. W. (2003). Male and female sensitivity to alcohol-induced brain damage. Alcohol Research and Health, 27, 181–185.
Hommer, D., Momenan, R., Kaiser, E. & Rawlings, R. (2001). Evidence for a gender-related effect of alcoholism on brain volumes. American Journal of Psychiatry, 158, 198–204.
Hommer, D., Momenan, R., Rawlings, R. et al. (1996). Decreased corpus callosum size among alcoholic women. Archives of Neurology, 53, 359–363.
Huestegge, L., Radach, R., Kunert, H. J. & Heller, D. (2002). Visual search in long-term cannabis users with early age of onset. Progress in Brain Research, 140, 377–394.
Iyo, M., Namba, H., Yanagisawa, M. et al. (1997). Abnormal cerebral perfusion in chronic methamphetamine abusers: a study using 99MTc-HMPAO and SPECT. Progress in Neuropsychopharmacology and Biological Psychiatry, 21, 789–796.
Jacobsen, L. K., Mencl, W. E., Pugh, K. R., Skudlarski, P. & Krystal, J. H. (2004). Preliminary evidence of hippocampal dysfunction in adolescent MDMA (“ecstasy”) users: possible relationship to neurotoxic effects. Psychopharmacology (Berlin), 173, 383–390.
Jentsch, J. D. & Taylor, J. R. (1999). Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology (Berlin), 146, 373–390.
Kanayama, G., Rogowska, J., Pope, H. G., Gruber, S. A. & Yurgelun-Todd, D. A. (2004). Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study. Psychopharmacology (Berlin), 176, 239–247.
Kantojarvi, L., Veijola, J., Laksy, K. et al. (2006). Co-occurrence of personality disorders with mood, anxiety, and substance use disorders in a young adult population. Journal of Personality Disorders, 20, 102–112.
Kempel, P., Lampe, K., Parnefjord, R., Hennig, J. & Kunert, H. J. (2003). Auditory-evoked potentials and selective attention: different ways of information processing in cannabis users and controls. Neuropsychobiology, 48, 95–101.
Kirisci, L., Tarter, R. E., Vanyukov, M., Reynolds, M. & Habeych, M. (2004). Relation between cognitive distortions and neurobehavior disinhibition on the development of substance use during adolescence and substance use disorder by young adulthood: a prospective study. Drug and Alcohol Dependence, 76, 125–133.
Kivisaari, R., Kahkonen, S., Puuskari, V. et al. (2004). Magnetic resonance imaging of severe, long-term, opiate-abuse patients without neurologic symptoms may show enlarged cerebrospinal spaces but no signs of brain pathology of vascular origin. Archives of Medical Research, 35, 395–400.
Kreek, M. J., Nielsen, D. A., Butelman, E. R. & Laforge, K. S. (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience, 8, 1450–1457.
Lee, T. M. & Pau, C. W. (2002). Impulse control differences between abstinent heroin users and matched controls. Brain Injury, 16, 885–889.
Lewinsohn, P. M., Hops, H., Roberts, R. E., Seeley, J. R. & Andrews, J. A. (1993). Adolescent psychopathology: I. Prevalence and incidence of depression and other DSM-III-R disorders in high school students. Journal of Abnormal Psychology, 102, 133–144.
Li, T., Chen, C. K., Hu, X. et al. (2004). Association analysis of the DRD4 and COMT genes in methamphetamine abuse. American Journal of Medical Genetics B Neuropsychiatry and Genetics, 129, 120–124.
Lubman, D. I., Hides, L. & Yucel, M. (2006). Inhalant abuse in youth: time for a coordinated response. Medical Journal of Australia, 185(6), 327–330.
Lubman, D. I., Yucel, M. & Pantelis, C. (2004). Addiction, a condition of compulsive behaviour? Neuroimaging and neuropsychological evidence of inhibitory dysregulation. Addiction, 99, 1491–1502.
Lyoo, I. K., Pollack, M. H., Silveri, M. M. et al. (2006). Prefrontal and temporal gray matter density decreases in opiate dependence. Psychopharmacology (Berlin), 184, 139–144.
Malhotra, A. K., Kestler, L. J., Mazzanti, C. et al. (2002). A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. American Journal of Psychiatry, 159, 652–654.
Mann, K., Agartz, I., Harper, C. et al. (2001). Neuroimaging in alcoholism: ethanol and brain damage. Alcoholism, Clinical and Experimental Research, 25, 104S–109S.
Maruff, P., Burns, C. B., Tyler, P., Currie, B. J. & Currie, J. (1998). Neurological and cognitive abnormalities associated with chronic petrol sniffing. Brain, 121(Pt 10), 1903–1917.
Matochik, J. A., Eldreth, D. A., Cadet, J. L. & Bolla, K. I. (2005). Altered brain tissue composition in heavy marijuana users. Drug and Alcohol Dependence, 77, 23–30.
Maxwell, J. A. (2005). Emerging research on methamphetamine. Current Opinion in Psychiatry, 18, 235–242.
McCardle, K., Luebbers, S., Carter, J. D., Croft, R. J. & Stough, C. (2004). Chronic MDMA (ecstasy) use, cognition and mood. Psychopharmacology (Berlin), 173, 434–439.
McGuire, P. (2000). Long term psychiatric and cognitive effects of MDMA use. Toxicology Letters, 112–113, 153–156.
Montoya, A. G., Sorrentino, R., Lukas, S. E. & Price, B. H. (2002). Long-term neuropsychiatric consequences of “ecstasy” (MDMA): a review. Harvard Review of Psychiatry, 10, 212–220.
Morgan, M. J., Impallomeni, L. C., Pirona, A. & Rogers, R. D. (2005). Elevated impulsivity and impaired decision-making in abstinent ecstasy (MDMA) users compared to polydrug and drug-naive controls. Neuropsychopharmacology, 31(7), 1562–1573.
Morgan, M. J., Mcfie, L., Fleetwood, H. & Robinson, J. A. (2002). Ecstasy (MDMA): are the psychological problems associated with its use reversed by prolonged abstinence? Psychopharmacology (Berlin), 159, 294–303.
Nordahl, T. E., Salo, R. & Leamon, M. (2003). Neuropsychological effects of chronic methamphetamine use on neurotransmitters and cognition: a review. Journal of Neuropsychiatry and Clinical Neuroscience, 15, 317–325.
Nordahl, T. E., Salo, R., Natsuaki, Y. et al. (2005). Methamphetamine users in sustained abstinence: a proton magnetic resonance spectroscopy study. Archives of General Psychiatry, 62, 444–452.
Nordahl, T. E., Salo, R., Possin, K. et al. (2002). Low N-acetyl-aspartate and high choline in the anterior cingulum of recently abstinent methamphetamine-dependent subjects: a preliminary proton MRS study. Magnetic resonance spectroscopy. Psychiatry Research, 116, 43–52.
Ornstein, T. J., Iddon, J. L., Baldacchino, A. M. et al. (2000). Profiles of cognitive dysfunction in chronic amphetamine and heroin abusers. Neuropsychopharmacology, 23, 113–126.
Parsons, O. A. & Nixon, S. J. (1998). Cognitive functioning in sober social drinkers: a review of the research since 1986. Journal of Studies on Alcoholism, 59, 180–190.
Parsons, O. A. (1998). Neurocognitive deficits in alcoholics and social drinkers: a continuum? Alcoholism, Clinical and Experimental Research, 22, 954–961.
Pau, C. W., Lee, T. M. & Chan, S. F. (2002). The impact of heroin on frontal executive functions. Archives of Clinical Neuropsychology, 17, 663–670.
Paus, T. (2005). Mapping brain maturation and cognitive development during adolescence. Trends in Cognitive Science, 9, 60–68.
Paus, T., Zijdenbos, A., Worsley, K. et al. (1999). Structural maturation of neural pathways in children and adolescents: in vivo study. Science, 283, 1908–1911.
Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H. & Lim, K. O. (1997). Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcoholism, Clinical and Experimental Research, 21, 521–529.
Pope, H. G., Jr. & Yurgelun-Todd, D. (1996). The residual cognitive effects of heavy marijuana use in college students. Journal of the American Medical Association, 275, 521–527.
Pope, H. G., Jr., Gruber, A. J., Hudson, J. I. et al. (2003). Early-onset cannabis use and cognitive deficits: what is the nature of the association? Drug and Alcohol Dependence, 69, 303–310.
Pope, H. G., Jr., Gruber, A. J., Hudson, J. I., Huestis, M. A. & Yurgelun-Todd, D. (2001). Neuropsychological performance in long-term cannabis users. Archives of General Psychiatry, 58, 909–915.
Rippeth, J. D., Heaton, R. K., Carey, C. L. et al. (2004). Methamphetamine dependence increases risk of neuropsychological impairment in HIV infected persons. Journal of the International Neuropsychology Society, 10, 1–14.
Rogers, R. D. & Robbins, T. W. (2001). Investigating the neurocognitive deficits associated with chronic drug misuse. Current Opinion in Neurobiology, 11, 250–257.
Rogers, R. D., Everitt, B. J., Baldacchino, A. et al. (1999). Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology, 20, 322–339.
Rosenberg, N. L., Grigsby, J., Dreisbach, J., Busenbark, D. & Grigsby, P. (2002). Neuropsychologic impairment and MRI abnormalities associated with chronic solvent abuse. Journal of Toxicology Clinical and Toxicology, 40, 21–34.
Salo, R., Nordahl, T. E., Possin, K. et al. (2002). Preliminary evidence of reduced cognitive inhibition in methamphetamine-dependent individuals. Psychiatry Research, 111, 65–74.
Scheier, L. M. & Botvin, G. J. (1995). Effects of early adolescent drug use on cognitive efficacy in early-late adolescence: a developmental structural model. Journal of Substance Abuse, 7, 379–404.
Scheurich, A. (2005). Neuropsychological functioning and alcohol dependence. Current Opinion in Psychiatry, 18, 319–323.
Smith, A., Fried, P., Hogan, M. & Cameron, I. (2004). The effects of prenatal and current marijuana exposure on response inhibition: a functional magnetic resonance imaging study. Brain and Cognition, 54, 147–149.
Solowij, N., Michie, P. T. & Fox, A. M. (1995). Differential impairments of selective attention due to frequency and duration of cannabis use. Biological Psychiatry, 37(10), 731–739.
Solowij, N., Respondek, C. & Ward, P. (2004). Functional magnetic resonance imaging indices of memory function in long-term cannabis users. In 2004 Symposium on the Cannabinoids (p. 89)). Burlington, VT: International Cannabinoid Research Society.
Solowij, N., Stephens, R. S., Roffman, R. A. et al. (2002). Cognitive functioning of long-term heavy cannabis users seeking treatment. Journal of the American Medical Association, 287, 1123–1131.
Spatt, J., Glawar, B. & Mamoli, B. (1997). A pure amnestic syndrome after MDMA (“ecstasy”) ingestion. Journal of Neurology, Neurosurgery and Psychiatry, 62, 418–419.
Steinberg, L. (2004). Risk taking in adolescence: what changes, and why? Annals of the New York Academy of Sciences, 1021, 51–58.
Steinberg, L. (2005). Cognitive and affective development in adolescence. Trends in Cognitive Science, 9, 69–74.
Stepp, S. D., Trull, T. J. & Sher, K. J. (2005). Borderline personality features predict alcohol use problems. Journal of Personality Disorders, 19, 711–722.
Strickland, T. L., Mena, I., Villanueva-Meyer, J. et al. (1993). Cerebral perfusion and neuropsychological consequences of chronic cocaine use. Journal of Neuropsychiatry and Clinical Neuroscience, 5, 419–427.
Sullivan, E. V., Rosenbloom, M. J. & Pfefferbaum, A. (2000b). Pattern of motor and cognitive deficits in detoxified alcoholic men. Alcoholism, Clinical and Experimental Research, 24, 611–621.
Sullivan, E. V., Rosenbloom, M. J., Lim, K. O. & Pfefferbaum, A. (2000a). Longitudinal changes in cognition, gait, and balance in abstinent and relapsed alcoholic men: relationships to changes in brain structure. Neuropsychology, 14, 178–188.
Swartz, M. S., Wagner, H. R., Swanson, J. W. et al. (2006). Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study. Journal of Nervous and Mental Diseases, 194, 164–172.
Tarter, R. E., Kirisci, L., Mezzich, A. et al. (2003). Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. American Journal of Psychiatry, 160, 1078–1085.
Volkow, N. D., Chang, L., Wang, G. J. et al. (2001a). Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. American Journal of Psychiatry, 158, 2015–2021.
Volkow, N. D., Chang, L., Wang, G. J. et al. (2001b). Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. Journal of Neuroscience, 21, 9414–9418.
Volkow, N. D., Chang, L., Wang, G. J. et al. (2001c). Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. American Journal of Psychiatry, 158, 377–382.
Volkow, N. D., Wang, G. J., Hitzemann, R. et al. (1994). Recovery of brain glucose metabolism in detoxified alcoholics. American Journal of Psychiatry, 151, 178–183.
Wang, G. J., Volkow, N. D., Fowler, J. S. et al. (2003). Alcohol intoxication induces greater reductions in brain metabolism in male than in female subjects. Alcoholism, Clinical and Experimental Research, 27, 909–917.
Whittle, S., Allen, N. B., Lubman, D. I. & Yucel, M. (2006). The neurobiological basis of temperament: towards a better understanding of psychopathology. Neuroscience and Biobehavior Reviews, 30, 511–525.
Wilson, W., Mathew, R., Turkington, T. et al. (2000). Brain morphological changes and early marijuana use: a magnetic resonance and positron emission tomography study. Journal of Addictive Diseases, 19, 1–22.
Woods, S. P., Rippeth, J. D., Conover, E. et al. (2005). Deficient strategic control of verbal encoding and retrieval in individuals with methamphetamine dependence. Neuropsychology, 19, 35–43.
Yücel, M. & Lubman, D. I. (2007). Neuropsychological and neuroimaging evidence of behavioural dysregulation in human drug addiction: implications for diagnosis, treatment and prevention. Drug and Alcohol Review, 26, 33–39.
Yamanouchi, N., Okada, S., Kodama, K. et al. (1995). White matter changes caused by chronic solvent abuse. American Journal of Neuroradiology, 16, 1643–1649.
Yamanouchi, N., Okada, S., Kodama, K. et al. (1997). Effects of MRI abnormalities on WAIS-R performance in solvent abusers. Acta Neurologica Scandinavica, 96, 34–39.