Edited by William M. Lee
Edited by Roger Williams
Foreword by Jean-Pierre Benhamou
Foreword by Jacques Bernuau
Publisher: Cambridge University Press
Print Publication Year: 1996
Online Publication Date:May 2010
Chapter DOI: http://dx.doi.org/10.1017/CBO9780511575044.013
Significant hemodynamic changes are seen in acute liver failure (ALF) which resemble those seen in sepsis, including an elevated cardiac output and lowered systemic vascular resistance (Bihari et al. 1986). Patients with critical illness frequently demonstrate a covert tissue oxygen debt despite apparently adequate blood pressure and arterial oxygen saturation (Haupt et al. 1985). In a healthy individual, adjustments are made in pulmonary gas exchange, cardiac output, hemoglobin, oxygen binding, capillary resistance, and oxygen extraction ratio to maintain an adequate supply of oxygen to the cell in the face of changing energy demands. Failure to maintain an adequate oxygen uptake to cells appears to be related to a combination of factors resulting in an inability to regulate delivery and extraction of oxygen at a cellular level.
The basis for the microcirculatory dysfunction in critical illness is poorly understood, but evidence is accumulating to suggest the importance of interactions between the endothelium, exogenous factors, such as bacterial toxins and cytokines, specifically tumor necrosis factor (TNF) and interleukins (IL-1, IL-6). Endotoxin and other bacterial toxins lead to the production of cytokines by activated macrophages and may be maintained in the circulation because of impaired Kupffer cell function. Activation and consumption of platelets with formation of microthrombi within various organs, may lead to endothelial damage and release of further vasoactive compounds. This series of events, together with increased adhesion of activated leukocytes to endothelial cells, causes microcirculatory plugging with blood being shunted through non-nutritive arteriovenous channels.
Part One - Clinical Syndrome and Etiology
Part Two - Mechanisms of Disease and Multisystem Involvement
Part Three - Intensive Care Management
Part Four - Transplantation
Part Five - Artificial and Bioartificial Liver Devices
Part Six - Other Applications