1 - The Dissolution of Protein Coding Genes in Molecular Biology  pp. 3-25

The Dissolution of Protein Coding Genes in Molecular Biology

By Thomas Fogle

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The consensus gene, a methodological outcome of the rapid growth in molecular biology, is a collection of flexibly applied parameters derived from features of well-characterized genes. Broad flexibility unites research programs under one umbrella and simultaneously promotes the false impression that the molecular gene concept is an internally coherent universal. This suggests limitations for genomic interpretations of information content in biological systems and for explanatory models that use genes as a manipulative. Genomic referencing, the development of systemic relationships among DNA domains, will more fully interconnect molecular genetics to biology than the molecular gene alone. Advances in understanding regulation and expression of DNA and the current interest in large-scale sequencing will necessarily supervene on much of the attention currently bestowed on molecular genes.


The gene concept, long regarded as a unit of inheritance, undergoes continuous transformation to accommodate novel structures and modes of action. A little more than a decade after the rediscovery of Mendel's work in 1900, new analytical strategies emerged for mapping genes as loci in a linear array on a chromosome. During the 1940s, the one-gene — one-enzyme model revealed that genes act to generate specific cellular products, a precursor to the science of molecular genetics. In the years that followed, the gene underwent further change. First, the double helix model of DNA made famous by Watson and Crick revealed the physical structure for particulate inheritance. Later efforts clarified the biochemistry of gene expression. Today, in the era of genomic sequencing and intense effort to identify sites of expression, the declared goal is to search for genes, entities assumed to have physical integrity.